The human thalamic somatic sensory nucleus [ventral caudal (Vc)] shows neuronal mechanoreceptor-like responses to optimal stimuli for peripheral mechanoreceptors.
The human thalamic somatic sensory nucleus [ventral caudal (Vc)] shows neuronal mechanoreceptor-like responses to optimal stimuli for peripheral mechanoreceptors.
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人类丘脑体细胞感觉核 [腹侧尾部 (Vc)] 对周围机械感受器的最佳刺激表现出类似神经元机械感受器的反应。
DOI：
10.1152/jn.90990.2008
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发表时间：
2009
影响因子：
2.5
通讯作者：
Lenz,FA
中科院分区：
文献类型：
--
作者：
Weiss,N;Ohara,S;Johnson,KO;Lenz,FA
虽然人皮肤机械感受器对受控刺激的反应得到了很好的研究，但尚不清楚这些外周信号如何反映在人CNS的神经元活动中。我们现在测试这样的假设：人类丘脑主要躯体感觉核[腹侧尾侧（Vc）]中的单个神经元选择性地对四种机械感受器之一的最佳刺激做出反应。特定机械感受器的最佳刺激定义如下：Pacinian小体（PC），128 Hz振动;快速适应（RA），32或64 Hz振动;缓慢适应1型（SA 1），边缘;缓慢适应2型（SA 2），皮肤拉伸。19个神经元对至少一种最佳刺激有显著反应，17个神经元对一种刺激的反应显著大于对其他三种刺激的反应，包括7个PC相关神经元、7个RA样神经元、3个SA 1样神经元和2个SA 2样神经元。每个SA 1和SA 2样丘脑神经元对振动的反应频率低于边缘或拉伸，但不显着。除了在PC相关的神经元的情况下，这些丘脑神经元的感受野（RF）的大小大于相应的mechanoreceptor。Von Frey阈值高于相应的人RA和SA 1机械感受器。这些结果表明，有一个收敛的途径传递输入从多个机械感受器的一种类型的单个丘脑神经元通过背柱。他们也是一致的存在灵长类丘脑元素的方式和躯体异位isorepresentation。
Although the response of human cutaneous mechanoreceptors to controlled stimuli is well studied, it is not clear how these peripheral signals may be reflected in neuronal activity of the human CNS. We now test the hypothesis that individual neurons in the human thalamic principal somatic sensory nucleus [ventral caudal (Vc)] respond selectively to the optimal stimulus for one of the four mechanoreceptors. The optimal stimuli for particular mechanoreceptors were defined as follows: Pacinian corpuscles (PC), vibration at 128 Hz; rapidly adapting (RA), vibration at 32 or 64 Hz; slowly adapting type 1 (SA1), edge; slowly adapting type 2 (SA2), skin stretch. Nineteen neurons had a significant response to at least one optimal stimulus, and 17 had a significantly greater response to one stimulus than to the other three, including 7 PC-related, 7 RA-like, 3 SA1-like, and 2 SA2-like neurons. One of each of the SA1- and SA2-like thalamic neurons responded to vibration with firing rates that were lower than those to edge or stretch but not significantly. Except in the case of PC-related neurons, the receptive field (RF) sizes were larger for these thalamic neurons than for the corresponding mechanoreceptor. Von Frey thresholds were higher than those for the corresponding human RA and SA1 mechanoreceptors. These results suggest that there is a convergence of pathways transmitting input from multiple mechanoreceptors of one type on single thalamic neurons via the dorsal columns. They are also consistent with the presence of primate thalamic elements of modality and somatotopic isorepresentation.