Glucose transporter expression in brain: Relationship to cerebral glucose utilization
Glucose transporter expression in brain: Relationship to cerebral glucose utilization
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DOI：
10.1159/000017333
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发表时间：
1998-07-01
影响因子：
2.9
通讯作者：
Simpson, IA
中科院分区：
文献类型：
--
作者：
Vannucci, SJ;Clark, RR;Simpson, IA
葡萄糖是哺乳动物大脑的主要能量来源。葡萄糖从血液输送到大脑需要通过血脑屏障的内皮细胞、神经元和神经胶质的质膜，这是由葡萄糖转运蛋白介导的。在脑葡萄糖代谢中起作用的两个主要葡萄糖转运蛋白亚型是GLUT1和GLUT3。GLUT1是血脑屏障、脉络膜丛、室管膜和胶质细胞的主要转运蛋白；GLUT3是神经元葡萄糖转运蛋白。这两种转运蛋白的表达水平与代谢需求和脑葡萄糖利用的区域速率一致。我们提出了几个实验范例，其中能量需求和/或底物供应的改变影响葡萄糖转运蛋白的表达。这些包括大鼠的正常大脑发育、阿尔茨海默病、体外神经元分化和大鼠的脱水。
Glucose is the principle energy source for mammalian brain. Delivery of glucose from the blood to the brain requires its transport across the endothelial cells of the blood-brain barrier and across the plasma membranes of neurons and glia, which is mediated by the facilitative glucose transporter proteins. The two primary glucose transporter isoforms which function in cerebral glucose metabolism are GLUT1 and GLUT3. GLUT1 is the primary transporter in the blood-brain barrier, choroid plexus, ependyma, and glia; GLUT3 is the neuronal glucose transporter. The levels of expression of both transporters are regulated in concert with metabolic demand and regional rates of cerebral glucose utilization. We present several experimental paradigms in which alterations in energetic demand and/or substrate supply affect glucose transporter expression. These include normal cerebral development in the rat, Alzheimer's disease, neuronal differentiation in vitro, and dehydration in the rat.