THE EXTRACELLULAR-MATRIX OF THE HUMAN OPTIC-NERVE
THE EXTRACELLULAR-MATRIX OF THE HUMAN OPTIC-NERVE
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DOI：
10.1001/archopht.1989.01070020291041
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发表时间：
1989-08-01
影响因子：
--
通讯作者：
WEINREB, RN
中科院分区：
文献类型：
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作者：
GOLDBAUM, MH;JENG, S;WEINREB, RN
视神经的神经纤维被细胞外基质包围和分割。用免疫染色剂，我们本地化的胶原蛋白I型通过VI，层粘连蛋白，和纤维连接蛋白在冰冻切片的细胞外基质的前板，板，和后板的人视神经。视神经的内界板具有与较厚的相邻视网膜内界板相似的细胞外成分。我们证实，筛板含有IV型胶原和层粘连蛋白，而巩膜不。层后视神经的隔表现为软脑膜的血管向内延伸。衬视神经的神经胶质管从层后视神经向前延伸穿过筛板，在视网膜色素上皮的前方终止。它不会将视神经与相邻的感觉视网膜分开。
The nerve fibers of the optic nerve are enclosed and segmented by extracellular matrix. With immunostains, we localized collagen types I through VI, laminin, and fibronectin in frozen sections of the extracellular matrix of the prelaminar, laminar, and retrolaminar human optic nerve. The internal limiting lamina of the optic nerve has an extracellular composition similar to the thicker adjacent retinal internal limiting lamina. We confirmed that the lamina cribrosa contains type IV collagen and laminin, whereas the sclera does not. The septa of the retrolaminar optic nerve appear as vascular inward extensions of the pia mater. The glial tube that lines the optic nerve extends forward from the retrolaminar optic nerve through the lamina cribrosa to end anteriorly at the retinal pigment epithelium. It does not separate the optic nerve from the adjacent sensory retina.