Rosmarinic acid stimulates liver regeneration through the mTOR pathway
Rosmarinic acid stimulates liver regeneration through the mTOR pathway
复制标题
迷迭香酸通过 mTOR 途径刺激肝脏再生
DOI：
10.1016/j.phymed.2016.09.010
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发表时间：
2016-12-01
期刊：
影响因子：
7.9
通讯作者：
He, Zhiyong
中科院分区：
文献类型：
--
作者：
Lou, Kaihan;Yang, Min;He, Zhiyong
背景：迷迭香（Rosmarinus offcinsalis L）在各种肝损伤情况下具有保肝功能。迷迭香的药理成分之一迷迭香酸对器官损伤（包括急性肝损伤）表现出保护作用。假设：我们假设 RA 刺激肝再生。研究设计：在本研究中，我们使用部分肝切除术（PH）研究 RA 对肝再生的影响和机制，这是一种经过充分验证的肝再生模型。 方法：我们使用2/3部分肝切除（PH）模型来诱导肝再生。 RA 在 PH 之前并与 PH 同时施用。通过肝脏体重指数（ILBW）以及增殖细胞核抗原（PCNA）和肝脏转氨酶的表达来评估再生过程。结果：迷迭香酸的施用基于mTOR/S6K途径的激活刺激肝细胞增殖。迷迭香酸治疗还可以挽救因 PH 导致的肝功能受损。结论：这些数据表明 RA 可能有助于促进肝再生。 (C) 2016 爱思唯尔有限公司。版权所有。
Background: Rosemary (Rosmarinus offcinsalis L) has a liver protection function under various conditions of liver damage. Rosmarinic acid, one of the pharmacological constituents of rosemary, exhibited protective effects against organ injury, including acute liver injury.Hypothesis: We hypothesize that RA stimulates liver regeneration.Study Design: In the present study, we investigated the effects and mechanism of RA administration on liver regeneration using partial hepatectomy (PH), a well-validated liver regeneration model in mice.Methods: We use a 2/3 partial hepatectomy (PH) model to induce liver regeneration. RA was administered prior to and simultaneously with PH. The regeneration process was estimated by the index of the liver to body weight (ILBW) and the expression of proliferating cell nuclear antigen (PCNA) and liver transaminases.Results: The administration of rosmarinic acid stimulated hepatocyte proliferation based on activation of the mTOR/S6K pathway. Rosmarinic acid treatment also rescued impaired liver function due to PH.Conclusion: These data demonstrate that RA is potentially useful to promote liver regeneration. (C) 2016 Elsevier GmbH. All rights reserved.