Metabolomic biomarkers and novel dietary factors associated with gestational diabetes in China
Metabolomic biomarkers and novel dietary factors associated with gestational diabetes in China
复制标题
与中国妊娠期糖尿病相关的代谢组生物标志物和新型饮食因素
DOI：
10.1007/s11306-018-1445-6
复制
发表时间：
2018-11-01
期刊：
影响因子：
3.6
通讯作者：
Baker, Philip N.
中科院分区：
文献类型：
--
作者：
Chen, Xuyang;de Seymour, Jamie V.;Baker, Philip N.
引言
妊娠期糖尿病（GDM）是在妊娠期首次发现的葡萄糖耐量受损；其发生与许多不良结局相关。GDM发生的机制尚未完全阐明，且很少有研究以中国参与者为对象。
目的
本研究旨在调查中国人群中与GDM相关的母体代谢组，并探索其与母体饮食的关系。
方法
从中国重庆招募了93名妊娠26 - 28周的参与者。使用气相色谱 - 质谱法和液相色谱 - 质谱法分析母体尿液、血清和头发的代谢组。使用一份含96项食物的频率调查问卷评估饮食摄入情况。
结果
在鉴定出的1064种代谢物中，病例组和对照组之间有73种存在显著差异（P
IntroductionGestational diabetes mellitus (GDM) is impaired glucose tolerance first recognised during pregnancy; its development is associated with many adverse outcomes. Mechanisms of GDM development are not fully elucidated and few studies have used Chinese participants.ObjectivesThe aim of this study was to investigate the maternal metabolome associated with GDM in a Chinese population, and explore the relationship with maternal diet.MethodsNinety-three participants were recruited at 26–28 weeks’ gestation from Chongqing, China. Maternal urine, serum, and hair metabolomes were analysed using gas and liquid chromatography–mass spectrometry. Dietary intake was assessed using a 96-item food frequency questionnaire.ResultsOf the 1064 metabolites identified, 73 were significantly different between cases and controls (P< 0.05), but only 2-aminobutyric acid had both a p- and q-value < 0.05. A “snack-based-dietary-pattern” was associated with an increased likelihood of GDM (odds ratio 2·1; 95% confidence interval 1.1–3.9). The association remained significant after adjustment for calorie intake but not food volume.ConclusionThis study provides a comprehensive characterization of the maternal metabolome. The snack-based dietary pattern associated with GDM suggests that timing and frequency of consumption are important factors in the relationship between maternal diet and GDM.