Coffee Reduces Risk for Hepatocellular Carcinoma: An Updated Meta-analysis
Coffee Reduces Risk for Hepatocellular Carcinoma: An Updated Meta-analysis
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DOI：
10.1016/j.cgh.2013.04.039
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发表时间：
2013-11-01
影响因子：
12.6
通讯作者：
La Vecchia, Carlo
中科院分区：
文献类型：
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作者：
Bravi, Francesca;Bosetti, Cristina;La Vecchia, Carlo
背景与目的：饮用咖啡被认为可以降低患肝细胞癌的风险。我们进行了流行病学研究的荟萃分析，以提供有关饮用咖啡如何影响肝癌风险的最新信息。方法：我们检索了PubMed/MEDLINE从1966年到2012年9月发表的关于饮用咖啡与肝癌或肝癌相关的病例对照或队列研究的原始文章。我们计算了任何、低咖啡和高咖啡消费与不喝咖啡的汇总相对风险(RR)。结果：16项研究中，饮用咖啡与不饮用咖啡的总相对危险度为0.60(95%可信区间，0.50-0.71)；8项病例对照研究的RR值为0.56(95%可信区间，0.42-0.75)；8项队列研究的RR值为0.64(95%可信区间，0.52-0.78)。与不喝咖啡相比，低咖啡消费的汇总相对危险度为0.72(95%CI，0.61~0.84)，高咖啡消费的汇总RR为0.44(95%CI，0.39~0.50)。每天喝一杯咖啡的总相对危险度为0.80(95%CI，0.77-0.84)。无论受试者的性别、饮酒、肝炎或肝病病史如何，咖啡与肝癌风险之间的负相关关系是一致的。结论：从这项荟萃分析来看，喝咖啡比不喝咖啡的人患肝癌的风险降低40%。这种反向关联可能部分或大部分存在，因为患有肝脏和消化系统疾病的患者减少了咖啡的摄入量。然而，咖啡已被证明会影响肝酶和肝硬变的发展，因此可以预防肝癌的发生。
BACKGROUND & AIMS: Coffee consumption has been suggested to reduce the risk for hepatocellular carcinoma (HCC). We performed a meta-analysis of epidemiological studies to provide updated information on how coffee drinking affects HCC risk.METHODS: We performed a PubMed/MEDLINE search of the original articles published in English from 1966 through September 2012, on case-control or cohort studies that associated coffee consumption with liver cancer or HCC. We calculated the summary relative risk (RR) for any, low, and high consumption of coffee vs no consumption. The cut-off point for low vs high consumption was set to 3 cups per day in 9 studies and 1 cup per day in 5 studies.RESULTS: The summary RR for any coffee consumption vs no consumption was 0.60 from 16 studies, comprising a total of 3153 HCC cases (95% confidence interval [CI], 0.50-0.71); the RRs were 0.56 from 8 case-control studies (95% CI, 0.42-0.75) and 0.64 from 8 cohort studies (95% CI, 0.52-0.78). Compared with no coffee consumption, the summary RR was 0.72 (95% CI, 0.61-0.84) for low consumption and 0.44 (95% CI, 0.39-0.50) for high consumption. The summary RR was 0.80 (95% CI, 0.77-0.84) for an increment of 1 cup of coffee per day. The inverse relationship between coffee and HCC risk was consistent regardless of the subjects' sex, alcohol drinking, or history of hepatitis or liver disease.CONCLUSIONS: From this meta-analysis, the risk of HCC is reduced by 40% for any coffee consumption vs no consumption. The inverse association might partly or largely exist because patients with liver and digestive diseases reduce their coffee intake. However, coffee has been shown to affect liver enzymes and development of cirrhosis, and therefore could protect against liver carcinogenesis.