Multidomain intervention and/or omega-3 in nondemented elderly subjects according to amyloid status
Multidomain intervention and/or omega-3 in nondemented elderly subjects according to amyloid status
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DOI：
10.1016/j.jalz.2019.07.008
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发表时间：
2019-11-01
影响因子：
14
通讯作者：
Andrieu, Sandrine
中科院分区：
文献类型：
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作者：
Delrieu, Julien;Payoux, Pierre;Andrieu, Sandrine
多领域阿尔茨海默病预防试验（MAPT）评估了补充omega-3脂肪酸、多领域干预（MI）或两者结合对认知的疗效。通过PET扫描评估脑淀粉样蛋白状态的影响。方法：参与者无痴呆，有记忆抱怨，限制在一个日常生活的工具活动，或缓慢的步态。主要结果是36个月内从基线到认知综合Z评分的变化。结果：淀粉样蛋白阴性组（167例）对认知功能无影响。在淀粉样蛋白阳性组（n = 102）中，我们观察到心肌梗死加omega-3脂肪酸组、心肌梗死单独组和安慰剂组的认知综合评分分别相差0.708和0.471。讨论：心肌梗死单独或联合omega-3脂肪酸与淀粉样蛋白状态阳性受试者的初级认知结局改善相关。(C) 2019年阿尔茨海默病协会。Elsevier Inc.出版。版权所有。
Introduction: The Multidomain Alzheimer Preventive Trial (MAPT) assessed the efficacy of omega-3 fatty acid supplementation, a multidomain intervention (MI), or a combination of both on cognition. Impact according to cerebral amyloid status was evaluated by PET scan.Methods: Participants were nondemented and had memory complaints, limitation in one instrumental activity of daily living, or slow gait. The primary outcome was a change from baseline in 36 months measured with a cognitive composite Z score.Results: No effect was observed on cognition in the negative amyloid group (n = 167). In the positive amyloid group (n = 102), we observed a difference of 0.708 and 0.471 in the cognitive composite score between the MI plus omega-3 fatty acid group, the MI alone group, and the placebo group, respectively.Discussion: MI alone or in combination with omega-3 fatty acids was associated with improved primary cognitive outcome in subjects with positive amyloid status. (C) 2019 the Alzheimer's Association. Published by Elsevier Inc. All rights reserved.