The Functional Architecture of the Infant Brain as Revealed by Resting-State fMRI
The Functional Architecture of the Infant Brain as Revealed by Resting-State fMRI
复制标题
DOI：
10.1093/cercor/bhq071
复制
发表时间：
2011-01-01
期刊：
影响因子：
3.7
通讯作者：
Lagercrantz, Hugo
中科院分区：
文献类型：
--
作者：
Fransson, Peter;Aden, Ulrika;Lagercrantz, Hugo
成年人大脑的功能网络拓扑结构最近开始使用静息态功能连接磁共振成像进行非侵入性映射，并使用源于图论的数学工具进行描述。以前的研究已经揭示了大脑区域之间的相互连接，即所谓的皮层枢纽，它作为信息汇聚区，可以捕捉到大脑结构如何支持人类行为以及如何受到疾病影响的关键方面。在这项研究中，我们提出的结果表明，皮质枢纽和他们相关的皮质网络主要局限于初级感觉和运动脑区在婴儿的大脑。我们在婴儿中的发现与成人中发现的情况形成鲜明对比，成人中大多数皮层枢纽和枢纽相关网络位于异模态关联皮层。我们的研究结果表明，婴儿的功能网络架构与支持任务是一个感知行动的性质。
The functional network topology of the adult human brain has recently begun to be noninvasively mapped using resting-state functional connectivity magnetic resonance imaging and described using mathematical tools originating from graph theory. Previous studies have revealed the existence of disproportionally connected brain regions, so called cortical hubs, which act as information convergence zones and supposedly capture key aspects of how the brain's architecture supports human behavior and how it is affected by disease. In this study, we present results showing that cortical hubs and their associated cortical networks are largely confined to primary sensory and motor brain regions in the infant brain. Our findings in infants stand in stark contrast to the situation found in adults where the majority of cortical hubs and hub-related networks are located in heteromodal association cortex. Our findings suggest that the functional network architecture in infants is linked to support tasks that are of a perception-action nature.