ALCOHOL CONSUMPTION AND MAJOR DEPRESSION IN THE GENERAL POPULATION: THE CRITICAL IMPORTANCE OF DEPENDENCE
ALCOHOL CONSUMPTION AND MAJOR DEPRESSION IN THE GENERAL POPULATION: THE CRITICAL IMPORTANCE OF DEPENDENCE
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DOI：
10.1002/da.22001
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发表时间：
2012-12-01
影响因子：
7.4
通讯作者：
Patten, Scott
中科院分区：
文献类型：
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作者：
Bulloch, Andrew;Lavorato, Dina;Patten, Scott
背景物质使用障碍和重度抑郁发作（MDEs）经常同时发生。饮酒可能导致抑郁发作的病因，反之亦然。在加拿大，国家人口健康调查（NPHS）在一个大型人群队列中对酒精使用和MDE的几个方面进行了12年的随访。我们评估了与不同饮酒模式相关的MDE发生率，并检查了有和无MDE的受访者中酒精滥用的发生率。方法NPHS是一项纵向研究，于1994年开始收集数据，其队列研究采用半年一次的访谈。这些访谈使用复合国际诊断访谈简表（CIDI-SFMD）评估MDE。另一个CIDI-SF模块在两次访谈中评估了酒精依赖。还评估了任何酒精消费，超过适度饮酒指南和酗酒。我们使用逻辑回归和比例风险模型来评估这些变量之间的纵向关系。结果酒精依赖的受访者MDE的风险较高，但任何酒精消费，超过适度饮酒和酗酒的指南。MDE的受访者没有表现出增加酒精消费，但酒精依赖的风险在抑郁症男性升高。结论酒依赖与MDE的双向关系具有直接的临床意义。酒精消费和MDE之间的关联没有观察到，除非依赖。酒精依赖增加了MDE的风险，MDE增加了酒精依赖的风险，但仅限于男性。抑郁和焦虑29：1058-1064，2012. (C)2012 Wiley Periodicals，Inc.
Background Substance use disorders and major depressive episodes (MDEs) often co-occur. Alcohol consumption may contribute to the aetiology of depressive episodes and/or vice versa. In Canada, the National Population Health Survey (NPHS) evaluated several aspects of alcohol use and MDE in a large population cohort over 12 years of follow-up. We evaluated the incidence of MDE in relation to different patterns of alcohol use, and examined the incidence of alcohol misuse in respondents with and without MDE. Methods The NPHS is a longitudinal study that began data collection in 1994 and whose cohort has been followed with biannual interviews. These interviews assess MDE using the Composite International Diagnostic Interview Short Form for Major Depression (CIDI-SFMD). Another CIDI-SF module assessed alcohol dependence during two interviews. Any alcohol consumption, exceeding moderate drinking guidelines and binge drinking were also assessed. We used logistic regression and proportional hazards models to assess longitudinal relationships between these variables Results Respondents with alcohol dependence were at higher risk of MDE, but any alcohol consumption, exceeding guidelines for moderate drinking and binge drinking were not. Respondents with MDE showed no increase of alcohol consumption, but the risk of alcohol dependence was elevated in depressed men. Conclusion Of direct clinical significance is the bidirectional relationship between alcohol dependence and MDE. Associations between alcohol consumption and MDE were not observed except when dependence was indicated. Alcohol dependence increased the risk of MDE, and MDE increased the risk of alcohol dependence, but only in men. Depression and Anxiety 29: 1058-1064, 2012. (C) 2012 Wiley Periodicals, Inc.