Sero-Epidemiological Study of Selected Zoonotic and Abortifacient Pathogens in Cattle at a Wildlife-Livestock Interface in South Africa
Sero-Epidemiological Study of Selected Zoonotic and Abortifacient Pathogens in Cattle at a Wildlife-Livestock Interface in South Africa
复制标题
DOI：
10.1089/vbz.2019.2519
复制
发表时间：
2020-04-01
影响因子：
2.1
通讯作者：
Simpson, Gregory J. G.
中科院分区：
文献类型：
--
作者：
Adesiyun, Abiodun A.;Knobel, Darryn L.;Simpson, Gregory J. G.
在南非克鲁格国家公园附近的一个公共农业区，对野生动物-牲畜界面的牛进行了一项横断面血清流行病学研究。采用酶联免疫吸附试验对184头牛进行了5种流产或人畜共患病原体（即贝氏柯克斯体、刚地弓形虫、流产嗜衣原体、犬新孢子虫和裂谷热病毒（RVFV））暴露筛查。此外，病毒中和试验用于确认RVFV抗体的存在。C. burnetii，T. gondii、弓形虫C. abortus，N.犬、RVFV抗体阳性率分别为38.0%、32.6%、20.7%、1.6%和0.5%，且不同地点之间存在差异（p < 0.001）。C. burnetii和T.弓形虫在地理位置上具有高度的聚类性（ICC = 0.57），而弓形虫在地理位置上具有高度的聚类性（ICC = 0.57）。中度流产（ICC = 0.11）。血清阳性率与性别和年龄无关，除了C。流产，其血清阳性率与年龄正相关（p = 0.01）。混合感染以C. burnetii和T.弓形虫15.2%; burnetii，T. gondii和C.流产（13.0%）。对牛的五种流产病原体的血清学检测表明，可能对畜牧业农民造成经济损失，对家畜的健康造成影响，通过牲畜-野生动物界面传播，以及人畜共患传染病的风险。这是T.在南非的牛感染弓形虫，而暴露于C. burnetii，C. abortus和N.在该国野生动物-牲畜交界处的牛中首次报告了犬感染。
A cross sectional sero-epidemiological study was conducted on cattle in a communal farming area adjacent to Kruger National Park at a wildlife-livestock interface in South Africa. A total of 184 cattle were screened for exposure to 5 abortifacient or zoonotic pathogens, namely Coxiella burnetii, Toxoplasma gondii, Chlamydophila abortus, Neospora caninum, and Rift Valley fever virus (RVFV) using enzyme-linked immunosorbent assays. In addition, the virus neutralization test was used to confirm the presence of antibodies to RVFV. The seroprevalence of C. burnetii, T. gondii, C. abortus, N. caninum, and RVFV antibodies was 38.0%, 32.6%, 20.7%, 1.6%, and 0.5%, respectively, and varied between locations (p < 0.001). Seroprevalence of C. burnetii and T. gondii was highly clustered by location (intraclass correlation coefficient [ICC] = 0.57), and that of C. abortus moderately so (ICC = 0.11). Seroprevalence was not associated with sex or age for any pathogen, except for C. abortus, for which seroprevalence was positively associated with age (p = 0.01). The predominant mixed infections were C. burnetii and T. gondii (15.2%) and C. burnetii, T. gondii, and C. abortus (13.0%). The serological detection of the five abortifacient pathogens in cattle indicates the potential for economic losses to livestock farmers, health impacts to domestic animals, transmission across the livestock-wildlife interface, and the risk of zoonotic transmission. This is the first documentation of T. gondii infection in cattle in South Africa, while exposure to C. burnetii, C. abortus, and N. caninum infections is being reported for the first time in cattle in a wildlife-livestock interface in the country.