Association of chemerin levels in synovial fluid with the severity of knee osteoarthritis
Association of chemerin levels in synovial fluid with the severity of knee osteoarthritis
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DOI：
10.3109/1354750x.2011.634028
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发表时间：
2012-02-01
期刊：
影响因子：
2.6
通讯作者：
Zhang, Bo
中科院分区：
文献类型：
--
作者：
Huang, Ke;Du, Gang;Zhang, Bo
内容：Chemerin与炎症反应密切相关。目的：探讨膝关节骨性关节炎（OA）患者血清和滑液（SF）中Chemerin水平与疾病严重程度的关系。方法：124例膝关节OA患者和76例健康对照者参加了本研究。结果：血清Chemerin水平显著高于配对的SF。结论：膝关节骨性关节炎患者关节液中Chemerin水平与疾病严重程度相关，可能参与了OA发生、发展的病理生理过程。
Context: Chemerin has been implicated to be correlated with inflammation.Objective: This study aims to determine the association of chemerin levels in serum and synovial fluid (SF) with the disease severity of patients with knee Osteoarthritis (OA).Methods: 124 patients with knee OA and 76 healthy controls were enrolled in this study.Results: Chemerin levels in serum were significant higher with regard to paired SF. Chemerin levles in SF of knee OA patients were correlated with disease severity evaluated by KL grading criteria.Conclusion: Chemerin levels may be involved in the pathophysiology of the development and progression of OA.