Polymethoxyflavones in orange peel extract prevent skeletal muscle damage induced by eccentric exercise in rats
Polymethoxyflavones in orange peel extract prevent skeletal muscle damage induced by eccentric exercise in rats
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DOI：
10.1093/bbb/zbaa036
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发表时间：
2021-02-18
影响因子：
1.6
通讯作者：
Sato, Ryuichiro
中科院分区：
文献类型：
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作者：
Suzuki, Toshihide;Shimizu, Makoto;Sato, Ryuichiro
柑橘类水果皮中含有的多甲氧基黄酮（PMF）具有抗炎、抗癌和抗抑郁作用。然而，它们对骨骼肌的影响尚不清楚。我们研究了 PMF 是否可以预防大鼠离心运动引起的骨骼肌损伤。下坡跑 90 分钟增加了骨骼肌（尤其是股外侧肌）中炎症细胞因子、单核细胞趋化蛋白-1 (MCP-1) 和白细胞介素 1 β (IL-1 β) 的水平，以及血浆肌酸激酶水平。下坡跑前 30 分钟单次口服橙皮提取物 (OPE) 可减弱这些增加。 OPE 的主要 PMFs 川陈皮素、sinensetin、3,5,6,7,8,3',4'-七甲氧基黄酮和橘皮素的混合物也对肌肉损伤显示出类似的效果。这些结果表明 OPE 对偏心运动引起的骨骼肌损伤具有保护作用，并且这种作用可能归因于 4 个主要 PMF。
Polymethoxyflavones (PMFs) contained in the peel of citrus fruits have anti-inflammatory, anticancer, and antidepressant effects. However, their effects on skeletal muscle are unknown. We investigated whether PMFs could prevent skeletal muscle damage induced by eccentric exercise in rats. Downhill running for 90 min increased the levels of the inflammatory cytokines, monocyte chemotactic protein-1 (MCP-1), and interleukin-1 beta (IL-1 beta) in skeletal muscles, especially in vastus lateralis, and the plasma creatine kinase levels. These increases were attenuated by a single oral administration of orange peel extract (OPE) 30 min before downhill running. A mixture of nobiletin, sinensetin, 3,5,6,7,8,3 ',4 '-heptamethoxyflavone, and tangeretin, which are the major PMFs of OPE, also showed similar effects on muscle damage. These results suggest that OPE has a protective effect against eccentric exercise-induced skeletal muscle damage, and that the effects may be attributed to the 4 major PMFs.