Updated Views on Neutrophil Responses in Ischemia-Reperfusion Injury.
Updated Views on Neutrophil Responses in Ischemia-Reperfusion Injury.
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DOI：
10.1097/tp.0000000000004221
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发表时间：
2022-12-01
期刊：
影响因子：
6.2
通讯作者：
中科院分区：
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缺血再灌注损伤是器官移植过程中不可避免的事件，是肺、心、肝、肾移植受者早期移植物功能障碍的主要危险因素。最近的研究表明，受体中性粒细胞是这一过程的关键介质，也发现移植后早期的先天免疫反应最终可以增强获得性同种免疫，并影响晚期移植的结果。在这里，我们讨论了在实体器官移植中涉及缺血介导的移植物损伤后中性粒细胞募集和激活的信号通路，重点是同种异体肺移植，这是最近研究的焦点。这些发现提示了针对移植受者的缺血再灌注损伤介导的移植物功能障碍的新的治疗干预措施。
Ischemia-reperfusion injury is an inevitable event during organ transplantation and represents a primary risk factor for the development of early graft dysfunction in lung, heart, liver, and kidney transplant recipients. Recent studies have implicated recipient neutrophils as key mediators of this process and have also found that early innate immune responses after transplantation can ultimately augment adaptive alloimmunity and impact late graft outcomes. Here, we discuss signaling pathways involved in neutrophil recruitment and activation after ischemia-mediated graft injury in solid organ transplantation with an emphasis on lung allografts, which have been the focus of recent studies. These findings suggest novel therapeutic interventions that target ischemia-reperfusion injury-mediated graft dysfunction in transplant recipients.