Noninvasive vascular imaging in fluorescent tumors using multispectral unmixing
Noninvasive vascular imaging in fluorescent tumors using multispectral unmixing
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DOI：
10.2144/000112946
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发表时间：
2008-10-01
期刊：
影响因子：
2.7
通讯作者：
El-Deiry, Wafik S.
中科院分区：
文献类型：
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作者：
Mayes, Patrick A.;Dicker, David T.;El-Deiry, Wafik S.
动物模型中肿瘤血管的无创性成像为研究肿瘤血管生成的生物学以及监测抗血管治疗的效果提供了重要工具。通过使用体内多光谱荧光成像，我们发现了与小鼠肿瘤血管相关的明显光谱特征。这种独特的光谱特征允许在不使用血管成像探针的情况下对肿瘤血管进行成像和量化。这种非侵入性的血管成像技术允许实时分析肿瘤血管形成，这为在临床前动物模型中监测抗血管生成治疗的效果提供了一个强大而有效的工具。
Noninvasive imaging of tumor vascularization in animal models provides an important tool for studying the biology of tumor angiogenesis as well as monitoring the effects of antiangtogentic therapies. Through the use of in vivo multispectral fluorescent imaging, we have discovered a distinct spectral signature associated with blood vessels present influorescent tumors in mice. This unique spectral signature allows for the tumor vasculature to be imaged and quantified without the use of vascular imaging probes. This noninvasive vascular imaging technique allows for real-time analysis of tumor vascularization, which provides a powerful and efficient tool for monitoring the effect of antiangiogenic therapies in preclinical animal models.