Mechanisms and uses of hydrogen exchange
Mechanisms and uses of hydrogen exchange
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DOI：
10.1016/s0959-440x(96)80090-x
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发表时间：
1996-02-01
影响因子：
6.8
通讯作者：
Mayne, L
中科院分区：
文献类型：
--
作者：
Englander, SW;Sosnick, TR;Mayne, L
最近的工作已经在很大程度上完成了我们对非结构化蛋白质和核酸的氢交换化学的理解。一些决定天然大分子氢交换行为的高能结构波动已经得到解释;其他的仍然难以捉摸。越来越多的应用正在利用氢交换行为来研究困难的分子系统，并引出蛋白质结构，动力学和能量学方面的信息。
Recent work has largely completed our understanding of the hydrogen-exchange chemistry of unstructured proteins and nucleic acids. Some of the high-energy structural fluctuations that determine the hydrogen-exchange behavior of native macromolecules have been explained; others remain elusive. A growing number of applications are exploiting hydrogen-exchange behavior to study difficult molecular systems and elicit otherwise inaccessible information on protein structure, dynamics and energetics.