Xenon-129 MR imaging and spectroscopy of rat brain using arterial delivery of hyperpolarized xenon in a lipid emulsion
Xenon-129 MR imaging and spectroscopy of rat brain using arterial delivery of hyperpolarized xenon in a lipid emulsion
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DOI：
10.1002/mrm.1180
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发表时间：
2001-08-01
影响因子：
3.3
通讯作者：
Constantinesco, A
中科院分区：
文献类型：
--
作者：
Duhamel, G;Choquet, P;Constantinesco, A
溶解在脂肪乳剂中的超极化 Xe-129 构成了一种 NMR 示踪剂，可以注入血流中，从而实现血流测量和灌注成像。 1.5 秒内将少量（0.15 ml）这种示踪剂注射到大鼠颈动脉中，并在 2.35 T 下采集 Xe-129 MR 光谱和图像，以评估这种方法用于大脑研究的潜力。氙光谱始终显示出两个共振，相对于气体峰分别位于 194.5 ppm 和 199.0 ppm。两个峰获得的信噪比 (SNR) 足以（范围从 12 到 90）来跟踪它们的时间进程。获得的二维横向投影氙气图像的面内分辨率为每像素 900 µm（SNR 范围 8-15）。组织学分析显示，除了两只接受了三次注射的老鼠外，没有任何脑损伤。 (C) 2001 Wiley-Liss, Inc.
Hyperpolarized Xe-129 dissolved in a lipid emulsion constitutes an NMR tracer that can be injected into the blood stream, enabling blood-flow measurement and perfusion imaging. A small volume (0.15 ml) of this tracer was injected in 1.5 s in rat carotid and Xe-129 MR spectra and images were acquired at 2.35 T to evaluate the potential of this approach for cerebral studies. Xenon spectra consistently showed two resonances, at 194.5 ppm and 199.0 ppm relative to the gas peak. The signal-to-noise ratio (SNR) obtained for the two peaks was sufficient (ranging from 12 to 90) to follow their time courses. 2D transverse-projection xenon images were obtained with an in-plane resolution of 900 mum per pixel (SNR range 8-15). Histological analysis revealed no brain damage except in two rats that had received three injections. (C) 2001 Wiley-Liss, Inc.