Schlemm's canal and primary open angle glaucoma: Correlation between Schlemm's canal dimensions and outflow facility
Schlemm's canal and primary open angle glaucoma: Correlation between Schlemm's canal dimensions and outflow facility
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DOI：
10.1006/exer.1996.0012
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发表时间：
1996-01-01
影响因子：
3.4
通讯作者：
Ethier, CR
中科院分区：
文献类型：
--
作者：
Allingham, RR;deKater, AW;Ethier, CR
该研究的目的是检查正常和青光眼人眼中施累姆氏管（SC）的流出设施和形态测量之间的相关性。在 15 mmHg 的压力下进行灌注固定之前，对 10 只正常人眼和 5 只青光眼 (POAG) 人眼的流出设施进行了测量。使用形态测量分析系统对每个象限两个单独的部分（每只眼睛八个部分）进行分析。测量 SC 横截面积、周长和内壁长度。计数内壁内皮细胞核。当检查汇总数据时，发现设施和 SC 区域之间存在统计显着相关性（P 小于或等于 0 . 01）。最重要的是，与正常眼睛相比，POAG 眼睛的 SC 横截面积、SC 周长和 SC 内壁长度明显更小。如果检查 SC 过滤面积的减少，则仅 SC 内壁长度的减少就可以解释正常眼和 POAG 眼之间观察到的流出设施差异的大约 41-55%。青光眼人眼施累姆管的尺寸明显小于正常眼的施累姆管。 SC 尺寸的减小可能是由于 (C) 1996 学术出版社有限公司
The purpose of the study was to examine the correlation between outflow facility and morphometric measurements of Schlemm's canal (SC) in normal and glaucomatous human eyes. Outflow facility was measured in ten normal and five glaucomatous (POAG) human eyes prior to perfusion-fixation at a pressure of 15 mmHg. Two separate sections per quadrant (eight sections per eye) were analysed using a morphometric analysis system. SC cross sectional area, perimeter, and inner wall length were measured. Inner wall endothelial nuclei were counted. When pooled data were examined, a statistically significant correlation was found between facility and SC area (P less than or equal to 0 . 01). Most importantly, POAG eyes had a significantly smaller SC cross-sectional area, SC perimeter and SC inner wall length compared to normal eyes. If examined as a reduction in SC filtering area, this decrease in SC inner wall length alone could account for approximately 41-55 % of the difference in outflow facility observed between normal and POAG eyes. The dimensions of Schlemm's canal in glaucomatous human eyes were significantly smaller than those in normal eyes. This reduction in SC dimensions may account (C) 1996 Academic Press Limited