Common ALL with pre-B-cell features showing (8;14) and (14;18) chromosome translocations.
Common ALL with pre-B-cell features showing (8;14) and (14;18) chromosome translocations.
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具有前 B 细胞特征的常见 ALL 显示 (8;14) 和 (14;18) 染色体易位。
DOI：
10.1182/blood.v62.5.1142.bloodjournal6251142
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发表时间：
1983
期刊：
影响因子：
20.3
通讯作者：
S. Johnson
中科院分区：
文献类型：
--
作者：
G. Mufti;T. Hamblin;D. Oscier;S. Johnson
一个21岁的男性腹股沟淋巴结肿大和脾肿大。外周血显示高原始细胞计数。原始细胞的形态学和免疫学特征与15%前B细胞的常见急性淋巴细胞白血病（ALL）的诊断一致。使用甲氨蝶呤同步化技术对血液和骨髓细胞进行显带核型分析，发现存在（8;14）和（14;18）染色体易位，这一发现以前没有记录。这些发现的意义进行了讨论。
A 21-yr-old man presented with inguinal lymphadenopathy and splenomegaly. The peripheral blood showed a high blast cell count. The morphological and immunologic features of the blast cells were consistent with the diagnosis of common acute lymphoblastic leukemia (ALL) with 15% pre-B-cells. Banded karyotype analysis of the blood and the marrow cells, using the technique of methotrexate synchronization, revealed the presence of (8;14) and (14;18) chromosome translocations, a finding that has not been previously documented. The significance of these findings is discussed.