Acetazolamide protects against posthypoxic unstable breathing in the C57BL/6J mouse.
Acetazolamide protects against posthypoxic unstable breathing in the C57BL/6J mouse.
复制标题
乙酰唑胺可防止 C57BL/6J 小鼠缺氧后呼吸不稳定。
DOI：
10.1152/japplphysiol.01287.2006
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发表时间：
2007
期刊：
影响因子：
--
通讯作者：
Strohl,KingmanP
中科院分区：
文献类型：
--
作者：
Yamauchi,Motoo;Dostal,Jesse;Strohl,KingmanP
Acetazolamide (Acz), a carbonic anhydrase inhibitor, is used to manage periodic breathing associated with altitude and with heart failure. We examined whether Acz would alter posthypoxic ventilatory behavior in the C57BL/6J (B6) mouse model of recurrent central apnea. Experiments were performed with unanesthetized, awake adult male B6 mice (n= 9), ventilatory behavior was measured using flow-through whole body plethysmography. Mice were given an intraperitoneal injection of either vehicle or Acz (40 mg/kg), and 1 h later they were exposed to 1 min of 8% O2-balance N2(poikilocapnic hypoxia) or 12% O2-3% CO2-balance N2(isocapnic hypoxia) followed by rapid reoxygenation (100% O2). Hypercapnic response (8% CO2-balance O2) was examined in six mice. With Acz, ventilation, including respiratory frequency, tidal volume, and minute ventilation, in room air was significantly higher and hyperoxic hypercapnic ventilatory responsiveness was generally lower compared with vehicle. Poikilocapnic and isocapnic hypoxic ventilatory responsiveness were similar among treatments. One minute after reoxygenation, animals given Acz exhibited posthypoxic frequency decline, a lower coefficient of variability for frequency, and no tendency toward periodic breathing, compared with vehicle treatment. We conclude that Acz improves unstable breathing in the B6 model, without altering hypoxic response or producing short-term potentiation, but with some blunting of hypercapnic responsiveness.
