Factors Associated with Health-Related Quality of Life in Late-Stage Parkinson's Disease
Factors Associated with Health-Related Quality of Life in Late-Stage Parkinson's Disease
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DOI：
10.1002/mdc3.13186
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发表时间：
2021-03-23
影响因子：
4
通讯作者：
Schrag, Anette
中科院分区：
文献类型：
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作者：
Rosqvist, Kristina;Odin, Per;Schrag, Anette
背景：关于晚期帕金森病（PD）健康相关生活质量（HRQoL）的知识有限。目的：评估影响晚期PD患者HRQoL的相关因素，重点关注医疗保健服务。方法：晚期帕金森病护理（CLaSP）项目是迄今为止规模最大的晚期帕金森病研究。目前的研究分析了来自6个欧洲国家的401例患者的数据，这些患者使用8项PD问卷对无痴呆患者的HRQoL进行了评估。在线性回归分析中评估和检查可能与HRQoL相关的因素。结果：在所有NMSS领域中，较好的HRQoL与生活在家中、更大的日常生活活动独立性（Schwab和England量表）、较轻的疾病（Hoehn和Yahr分期）、较好的运动功能（统一PD评定量表第III部分）和较低的非运动症状负担（非运动症状量表[NMSS]）相关。在过去的3个月内，有PD专科医生作为PD医师，与PD护士有联系，没有住院治疗与较好的HRQoL相关，但看过物理治疗师或职业治疗师与较差的HRQoL相关。结论：研究结果强调了优化运动和多种非运动症状治疗对改善晚期PD患者HRQoL的重要性。pd特定的医疗保健资源，特别是pd护士，在解决问题以改善这一人群的HRQoL方面可能很重要。最近看过物理治疗师或职业治疗师的患者的HRQoL较差可能反映了基于本研究未测量的因素的转诊。
Background: There is limited knowledge on health-related quality of life (HRQoL) in late-stage Parkinson's disease (PD).Objective: To assess factors associated with HRQoL in patients with late-stage PD, with a focus on health care provision.Methods: The Care of Late Stage Parkinsonism (CLaSP) project is the largest study on late-stage PD to date. The current study analyzed data of 401 patients from 6 European countries in whom HRQoL was assessed with the 8-item PD Questionnaire in patients without dementia. Factors potentially associated with HRQoL were assessed and examined in linear regression analyses.Results: Better HRQoL was associated with living at home, greater independence in activities of daily living (Schwab and England Scale), less severe disease (Hoehn and Yahr stage), better motor function (Unified PD Rating Scale Part III), and lower non-motor symptoms burden (Non-Motor Symptoms Scale [NMSS]) across all NMSS domains. Having a PDspecialist as physician for PD, contact with a PDnurse, and no hospital admission during the past 3 months were associated with better HRQoL, but having seen a physiotherapist or occupational therapist was associated with worse HRQoL.Conclusions: The results emphasize the importance of optimizing treatment for motor and multiple non-motor symptoms to improve HRQoL in patients with late-stage PD. PD-specific health care resources, particularly PDnurses, are likely important in addressing issues to improve HRQoL in this population. Worse HRQoL in those who had recently seen a physiotherapist or occupational therapist may reflect referral based on factors not measured in this study.