Drug-Induced Lupus Anticoagulants and Antiphospholipid Antibodies
Drug-Induced Lupus Anticoagulants and Antiphospholipid Antibodies
复制标题
DOI：
10.1007/s11926-011-0227-1
复制
发表时间：
2012-02-01
影响因子：
5
通讯作者：
Roubey, Robert A. S.
中科院分区：
文献类型：
--
作者：
Dlott, Jeffrey S.;Roubey, Robert A. S.
狼疮抗凝剂(LA)是免疫球蛋白(IgG、IgM和/或IgA)，其干扰一种或多种磷脂依赖性体外凝血测试，例如活化部分凝血活酶时间(aPTT)、高岭土凝血时间(KCT)、稀释拉塞尔毒蛇毒液时间(dRVVT)和稀释 凝血酶原时间 (dPT)。 LA 可见于多种临床情况，包括原发性抗磷脂综合征 (APS)、系统性红斑狼疮 (SLE)、其他自身免疫性疾病、继发于感染、恶性肿瘤以及与某些药物相关的疾病。与抗磷脂综合征和其他自身免疫性疾病相关的 LA 识别某些磷脂结合蛋白（β(2)-糖蛋白 Iβ(2)GPI] 或凝血酶原）。许多药物被认为可能导致 LA，尽管大多数此类病例仅限于少数人。药物引起的 LA 具有异质性，其实验室检查结果以及相关的临床并发症各不相同。本文综述了有关药物诱导的 LA 及其潜在诱导机制的英国医学文献。
Lupus anticoagulants (LA) are immunoglobulins (IgG, IgM, and/or IgA) which interfere with one or more of phospholipid-dependent in vitro coagulation tests, eg, activated partial thromboplastin time (aPTT), kaolin clotting time (KCT), dilute Russell viper venom time (dRVVT), and dilute prothrombin time (dPT). LAs may be seen in a variety of clinical settings including the primary antiphospholipid syndrome (APS), systemic lupus erythematosus (SLE), other autoimmune diseases, secondary to infections, malignancies, and in association with certain drugs. LAs associated with the antiphospholipid syndrome and other autoimmune disease recognize certain phospholipid-binding proteins (beta(2)-glycoprotein I[beta(2)GPI] or prothrombin). Many drugs have been implicated as possibly causing LAs, although the majority of such cases are limited to a select few. Drug-induced LAs are heterogeneous, differing in laboratory findings as well as related clinical complications. This paper reviews the English medical literature on drug-induced LA and potential mechanisms of induction.