Small dense LDL cholesterol measured by homogeneous assay in Japanese healthy controls, metabolic syndrome and diabetes patients with or without a fatty liver
Small dense LDL cholesterol measured by homogeneous assay in Japanese healthy controls, metabolic syndrome and diabetes patients with or without a fatty liver
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DOI：
10.1016/j.cca.2014.07.017
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发表时间：
2015-01-01
影响因子：
5
通讯作者：
Murakami, Masami
中科院分区：
文献类型：
--
作者：
Kikkawa, Koji;Nakajima, Katsuyuki;Murakami, Masami
背景：测定健康对照组、糖尿病(T2 DM)和代谢综合征(METS)伴或不伴脂肪肝的日本人群的血清sdLDL-C水平。方法：采用均相法测定正常对照组、METS和T2 DM患者(n=5255)的血脂和脂蛋白(包括sdLDL-C)。根据日本的甲硫氨酸和2型糖尿病诊断标准，筛选出甲硫氨酸和初级甲硫氨酸(Pre-Met)组以及12例糖尿病和初级期2型糖尿病(Pre-DM)组。结果：sdLDL-C第75百分位数男性为27.5 mg/dl，女性为23.3 mg/dl，且随年龄增长而增加。METS前期和T2 DM前期患者的sdLDL-C和sdLDL-C/LDL-C显著高于健康对照组以及METS和T2 DM患者。脂肪肝组sdLDL-C水平均显著高于非脂肪肝组。结论：蛋氨酸代谢前期、代谢综合征及2型糖尿病前期、2型糖尿病患者血清sdLDL-C水平明显高于健康对照组。脂肪肝显著升高血清sdLDL-C水平，多元回归分析证实脂肪肝是sdLDL-C的独立决定因素。(C)爱思唯尔出版的2014年。
Background: Serum small dense LDL-cholesterol (sdLDL-C) levels in healthy controls and the cases with diabetes (T2DM) and metabolic syndrome (MetS) with or without a fatty liver in a large, typical Japanese population was determined.Methods: The plasma lipids and lipoproteins, including sdLDL-C by homogeneous assay, were determined in controls, MetS and T2DM patients (n = 5255). The cases with MetS and preliminary MetS (pre-MetS) as well as 12DM and preliminary T2DM (pre-DM) were selected based on the Japanese criteria for MetS and T2DM. Fatty liver was diagnosed using the ultrasonography.Results: The 75th percentile values for sdLDL-C were 27.5 mg/dl for men and 23.3 mg/dl for women and increased with age. The concentrations of sdLDL-C and sdLDL-C/LDL-C were significantly higher in pre-MetS and pre-T2DM patients than healthy controls as well as in MetS and T2DM patients. Significantly higher sdLDL-C was found in cases with a fatty liver than without a fatty liver in all five groups.Conclusions: Significantly elevated sdLDL-C levels were found in pre-MetS, MetS and pre-T2DM, T2DM patients compared to the healthy controls. Fatty liver significantly enhanced serum sdLDL-C levels and the multiple regression analyses ascertained that fatty liver was an independent determinant for sdLDL-C. (C) 2014 Published by Elsevier B.V.