Prenatal risk factors and schizophrenia.
Prenatal risk factors and schizophrenia.
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DOI：
10.1586/14737175.2.1.53
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发表时间：
2002-01-01
影响因子：
4.3
通讯作者：
Brown, Alan S
中科院分区：
文献类型：
--
作者：
Brown, Alan S
本文重点介绍了表明产前环境因素与成人精神分裂症风险之间关系的主要研究结果。有证据表明，精神分裂症可能起源于大脑早期发育不良。然而，导致这种毁灭性疾病的因素仍然未知。虽然基因显然起着因果作用，但环境因素也可能起作用。我们讨论了产前生活中发生的几种候选环境暴露的证据，这些环境暴露可能会改变患精神分裂症的风险。这种被称为风险因素流行病学的研究的主要挑战是在精神分裂症患者中产生和测试这种接触，以便制定预防策略并更好地了解导致这种疾病的机制。
This article highlights major research findings that indicate a relation between prenatal environmental factors and the risk of adult schizophrenia. Evidence suggests that schizophrenia may have its origins in early maldevelopment of the brain. However, the factors responsible for this devastating disorder remain unknown. While genes clearly play a causal role, there is likely an environmental contribution as well. We discuss the evidence for several candidate environmental exposures that occur during prenatal life and that may modify the risk for developing schizophrenia. The main challenge of this type of research, termed risk-factor epidemiology, is to generate and test such exposures in subjects with schizophrenia, in order to develop preventive strategies and better understand the mechanisms that lead to this illness.