Ozone-induced alterations in collagen metabolism of rat lungs.
Ozone-induced alterations in collagen metabolism of rat lungs.
复制标题
臭氧诱导大鼠肺胶原代谢的改变。
DOI：
10.1016/0041-008x(79)90467-8
复制
发表时间：
1979
影响因子：
3.8
通讯作者：
W. Castleman
中科院分区：
文献类型：
--
作者：
J. Last;D. Greenberg;W. Castleman
将大鼠暴露于0.5至2.0 ppm的臭氧量，间隔1、2或3周。胶原蛋白合成率在他们的肺进行定量生化分析与肺切碎。对同一大鼠的不同肺叶进行了相关的组织学观察。在所有水平的臭氧测试，肺胶原蛋白的合成率显着升高，并观察到肺泡管壁的组织学上可辨别的纤维化。在研究的臭氧浓度范围内，暴露大鼠胶原合成率的升高是动物暴露于臭氧水平的线性函数。我们的结论是，大鼠暴露于接近环境水平的臭氧导致生化和组织学上可辨别的肺纤维化的变化，这表明这种影响可能会发生在臭氧水平或接近目前的环境空气质量标准，这种污染物。
Rats were exposed to amounts of ozone ranging from 0.5 to 2.0 ppm for intervals of 1, 2, or 3 weeks. Collagen synthesis rates in their lungs were quantitated by biochemical analyses performed with lung minces. Correlative histological observations were made in different lung lobes from the same rats. At all levels of ozone tested, collagen synthesis rates of the lungs were significantly elevated and histologically discernible fibrosis of the alveolar duct walls was observed. Within the range of ozone concentrations studied, the elevation of collagen synthesis rate in exposed rats was a linear function of the level of ozone to which the animals were exposed. We conclude that exposure of rats to near-ambient levels of ozone causes biochemically and histologically discernible fibrotic changes in their lungs, suggesting that such effects may occur at levels of ozone at or near the current ambient air quality standard for this pollutant.