Soluble adhesion molecules in Gilles de la Tourette's syndrome
Soluble adhesion molecules in Gilles de la Tourette's syndrome
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DOI：
10.1016/j.jns.2005.03.032
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发表时间：
2005-07-15
影响因子：
4.4
通讯作者：
Giovannoni, G
中科院分区：
文献类型：
--
作者：
Martino, D;Church, AJ;Giovannoni, G
为探讨TS患者的免疫应答及其与链球菌感染的关系，我们检测了TS患者血清中可溶性细胞间黏附分子-1(ICAM-1)、血管细胞黏附分子-1(VCAM-1)和E-选择素的水平，并与健康对照组和疾病对照组进行了比较。儿童和成人TS患者血清sVCAM-1和sE-选择素水平均显著升高，抗基底节抗体(ABGA)阳性成人TS患者sVCAM-1水平明显升高。未观察到黏附分子水平与临床严重程度或抗链球菌抗体的相关性。患有Sydenham舞蹈症和与链球菌感染(熊猫)相关的儿科自身免疫性神经精神疾病的儿童显示sICAM-1水平增加，但sVCAM-1和sE-选择素水平没有增加。这些结果为黏附分子和全身炎症在TS中的作用提供了初步证据，并支持了在这种情况下正在进行的免疫介导过程的假说。(C)2005 Elsevier B.V.保留所有权利。
To investigate the immune-mediated response in TS, and its relationship with streptococcal infection, we measured serum levels of soluble intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and E-selectin in patients with TS, compared to healthy and diseased controls. Soluble VCAM-1 and sE-selectin were significantly elevated in children and adults with TS, and sVCAM-1 was higher among anti-basal ganglia antibodies (ABGA)-positive adults With TS. No correlation of adhesion molecule levels to clinical severity or anti-streptococcal antibodies was observed. Children with Sydenham's chorea and paediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS) showed an increased level of sICAM-1, but not sVCAM-1 and sE-selectin. These results provide initial evidence for a role of adhesion molecules and systemic inflammation in TS, and Support the hypothesis of an ongoing immune-mediated process in this condition. (c) 2005 Elsevier B.V. All rights reserved.