Bioconcentration and effects of hexabromocyclododecane exposure in crucian carp (Carassius auratus)
Bioconcentration and effects of hexabromocyclododecane exposure in crucian carp (Carassius auratus)
复制标题
鲫鱼（Carassius auratus）接触六溴环十二烷的生物浓度和影响
DOI：
10.1007/s10646-018-1896-6
复制
发表时间：
2018-04-01
期刊：
影响因子：
2.7
通讯作者：
Nkoom, Matthew
中科院分区：
文献类型：
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作者：
Dong, Huike;Lu, Guanghua;Nkoom, Matthew
六溴环十二烷(HBCD)作为一种环状脂肪族溴化阻燃剂，已广泛应用于建筑隔热防火材料中。然而，关于水环境中暴露于六溴环十二烷的生物浓缩和影响的信息很少。为了研究六溴环十二烷在组织(肌肉和肝脏)中的生物浓度及其对生化和行为的影响，采用穿透暴露系统，研究了不同浓度(名义浓度为2、20、200 μg/L)的六氯环己烷对鲫鱼幼鱼的暴露7d。在肝脏和肌肉中，六氯环己烷的终浓度分别为0.60 ± 0.22 μg/g LW(脂重)和0.18 ± 0.02 μg/g LW(环境相关浓度)(2 μg/L)。暴露于HBCD后，鱼血浆中总甲状腺激素和总三碘甲腺原氨酸含量降低。200 μg/L组小鼠脑乙酰胆碱酯酶活性升高，游泳活动抑制，浅滩倾向增强。20和200 μg/L处理组小鼠的摄食率受到抑制。综上所述，六六六浓度比目前与环境有关的暴露浓度高出10-100倍，对本研究中测试的鱼类物种产生不利影响。这些结果表明，增加环境浓度和/或比鲤鱼更敏感的物种可能会受到六氯环己烷的不利影响。
As a cycloaliphatic brominated flame retardant, hexabromocyclododecane (HBCD) has been widely used in building thermal insulation and fireproof materials. However, there is little information on the bioconcentration as well as effects with respect to HBCD exposure in the aquatic environment. To investigate the bioconcentration of HBCD in tissues (muscle and liver) and its biochemical and behavioural effects, juvenile crucian carp (Carassius auratus) were exposed to different concentrations of technical HBCD (nominal concentrations, 2, 20, 200 μg/L) for 7 days, using a flow-through exposure system. HBCD was found to concentrate in the liver and muscle with a terminal concentration of 0.60 ± 0.22 μg/g lw (lipid weight) and 0.18 ± 0.02 μg/g lw, respectively, at an environmentally-relevant concentration (2 μg/L). The total thyroxine and total triiodothyronine in the fish plasma were lowered as a result of exposure to the HBCD. Acetylcholinesterase activity in the brain was increased, while swimming activity was inhibited and shoaling inclination was enhanced after exposure to 200 μg/L HBCD. Feeding rate was suppressed in the 20 and 200 μg/L treatment groups. In summary, HBCD concentrations 10–100× higher than the current environmentally-relevant exposures induced adverse effects in the fish species tested in this study. These results suggest that increasing environmental concentrations and/or species with higher sensitivity than carp might be adversely affected by HBCD.