ONSET OF PUBERTY AND DURATION OF FERTILITY IN RATS FED A RESTRICTED DIET
ONSET OF PUBERTY AND DURATION OF FERTILITY IN RATS FED A RESTRICTED DIET
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DOI：
10.1530/jrf.0.0570253
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发表时间：
1979-01-01
期刊：
影响因子：
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通讯作者：
HOLEHAN, AM
中科院分区：
文献类型：
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作者：
MERRY, BJ;HOLEHAN, AM
长期限制饮食，使CFY Sprague-Dawley雌性大鼠的体重为自由喂养动物的50%，可以延长寿命（LD50为1090天，而非704天）。所有的实验雌性老鼠在227天就进入了青春期，80%的老鼠在510天就能怀孕并断奶，这个年龄超过了对照组老鼠停止繁殖的年龄（450天）。约25%的实验大鼠能够在800日龄以上繁殖。
Chronic dietary restriction such that the body weight of CFY Sprague-Dawley female rats was 50% that of animals fed ad lib resulted in enhanced longevity (LD50 of 1090 days compared to 704 days). All the experimental females had reached puberty by 227 days and 80% were able to conceive and wean young at 510 days, an age beyond that at which the control rats had ceased to breed (450 days). Some (25%) of the experimental rats were able to breed at over 800 days of age.