Engineered Biomimetic Polymers as Tunable Agents for Controlling CaCO3 Mineralization
Engineered Biomimetic Polymers as Tunable Agents for Controlling CaCO3 Mineralization
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DOI：
10.1021/ja200595f
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发表时间：
2011-04-13
影响因子：
15
通讯作者：
DeYoreo, James J.
中科院分区：
文献类型：
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作者：
Chen, Chun-Long;Qi, Jiahui;DeYoreo, James J.
在自然界中，生物体使用肽和蛋白质来精确控制无机矿物质的成核和生长，并通过CaCO3的矿化来隔离CO2。在这里，我们报告了一类新型的序列特异性非天然聚合物称为类肽作为可调剂，显着控制碳酸钙矿化的开发。我们发现，由疏水性和阴离子单体组成的两亲性类肽表现出对方解石生长形态的高度控制，并且在仅50 nM的类肽浓度下，生长加速了前所未有的23倍，而类似分子量的酸性肽表现出仅类似于2或更小的增强因子。侧链化学、链长和浓度。这些发现为开发序列特异性非天然聚合物提供了指导方针，这些聚合物模拟天然肽或蛋白质在其直接矿化CaCO3的能力中的功能，着眼于其通过矿物捕集来封存CO2的应用。
In nature, living organisms use peptides and proteins to precisely control the nucleation and growth of inorganic minerals and sequester CO2 via mineralization of CaCO3. Here we report the exploitation of a novel class of sequence-specific non-natural polymers called peptoids as tunable agents that dramatically control CaCO3 mineralization. We show that amphiphilic peptoids composed of hydrophobic and anionic monomers exhibit both a high degree of control over calcite growth morphology and an unprecedented 23-fold acceleration of growth at a peptoid concentration of only 50 nM, while acidic peptides of similar molecular weight exhibited enhancement factors of only similar to 2 or less. We further show that both the morphology and rate controls depend on peptoid sequence, side-chain chemistry, chain length, and concentration. These findings provide guidelines for developing sequence-specific non-natural polymers that mimic the functions of natural peptides or proteins in their ability to direct mineralization of CaCO3, with an eye toward their application to sequestration of CO2 through mineral trapping.