In vivo areal modulus of elasticity estimation of the human tympanic membrane system:: modelling of middle ear mechanical function in normal young and aged ears
In vivo areal modulus of elasticity estimation of the human tympanic membrane system:: modelling of middle ear mechanical function in normal young and aged ears
复制标题
DOI：
10.1088/0031-9155/52/3/019
复制
发表时间：
2007-02-01
影响因子：
3.5
通讯作者：
Gregersen, Hans
中科院分区：
文献类型：
--
作者：
Gaihede, Michael;Liao, Donghua;Gregersen, Hans
鼓膜系统的准静态弹性特性可以用中耳模型确定的面弹性模量来描述。鼓膜对准静压变化的响应是由其弹性特性决定的。一些临床问题与这些有关，但研究很少，而且大多没有可比性。膜的弹性性能可以用面模量来描述，而这些也可能容易受到与年龄相关的变化的影响，这些变化反映在面模量的变化上。面模量由膜张力与相对于未变形表面积的表面积变化之间的关系决定。根据人鼓膜系统压力-体积变形实验数据，建立了中耳模型，确定了中耳模型在体内的张力-应变关系。测定了年轻组（n = 10）和老年组（n = 10）正常受试者的面模量。老年组鼓膜系统外侧和内侧位移的面积模量（平均值分别为0.686和0.828 kN m(-1)）小于年轻组（平均值分别为1.066和1.206 kN m(-1)），但差异不显著（2p分别为0.10和0.11）。在此基础上，建立了描述鼓膜系统总弹性特性的面模量。未来模型的改进包括通过三维有限元分析来精确确定鼓膜面积。在这项研究中，体内杨氏模量的估计比以前在体外发现的要小2 - 3倍。用面模量表示的弹性性能没有发现明显的年龄相关差异。
The quasi- static elastic properties of the tympanic membrane system can be described by the areal modulus of elasticity determined by a middle ear model. The response of the tympanic membrane to quasi- static pressure changes is determined by its elastic properties. Several clinical problems are related to these, but studies are few and mostly not comparable. The elastic properties of membranes can be described by the areal modulus, and these may also be susceptible to age-related changes reflected by changes in the areal modulus. The areal modulus is determined by the relationship between membrane tension and change of the surface area relative to the undeformed surface area. A middle ear model determined the tension - strain relationship in vivo based on data from experimental pressure - volume deformations of the human tympanic membrane system. The areal modulus was determined in both a younger ( n = 10) and an older ( n = 10) group of normal subjects. The areal modulus for lateral and medial displacement of the tympanic membrane system was smaller in the older group ( mean = 0.686 and 0.828 kN m(-1), respectively) compared to the younger group ( mean = 1.066 and 1.206 kN m(-1), respectively), though not significantly ( 2p = 0.10 and 0.11, respectively). Based on the model the areal modulus was established describing the summated elastic properties of the tympanic membrane system. Future model improvements include exact determination of the tympanic membrane area accounting for its shape via 3D finite element analyses. In vivo estimates of Young's modulus in this study were a factor 2 - 3 smaller than previously found in vitro. No significant age- related differences were found in the elastic properties as expressed by the areal modulus.