Molecular analyses of the interactions between human NK receptors and their HLA ligands
Molecular analyses of the interactions between human NK receptors and their HLA ligands
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DOI：
10.1016/s0198-8859(99)00159-7
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发表时间：
2000-01-01
期刊：
影响因子：
2.7
通讯作者：
Strominger, J
中科院分区：
文献类型：
--
作者：
Valés-Gómez, M;Reyburn, H;Strominger, J
NK细胞的细胞毒性受多个受体家族的作用调节。这些受体与其配体的相互作用控制不同的激活/抑制信号通路，并且正是这些信号的平衡决定了NK细胞的行为。所述的主要抑制途径开始为杀伤细胞免疫球蛋白样受体（KIR）对靶细胞经典I类HLA分子的识别或非经典I类分子HLA-E与CD 94/NKG 2-A异二聚体的结合。这些抑制性NK受体的激活对应物也已被描述，本次审查的重点是抑制性和激活性受体与其HLA配体的结合的分子细节。Human Immunology 61，28-38（2000）. (C)美国组织相容性和免疫遗传学学会，2000年。出版社：Elsevier Science Inc.
NK cell cytotoxicity is regulated by the action of multiple families of receptors. The interactions of these receptors with their ligands control different activating/inhibiting signal pathways and it is the balance of these signals which determines the behavior of the NK cell. The major described inhibitory pathways begin either with the recognition of a target cell classical class I HLA molecule by a killer cell immunologlobulin-like receptor (KIR) or the binding of the non-classical class I molecule HLA-E to the CD94/NKG2-A heterodimer. Activating counterparts to these inhibitory NK receptors have also been described and this review focuses on the molecular details of the binding of the inhibitory and activating receptors to their HLA ligands. Human Immunology 61, 28-38 (2000). (C) American Society for Histocompatibility and Immunogenetics, 2000. Published by Elsevier Science Inc.