Burden of respiratory syncytial virus in hospitalized infants and young children in Amman, Jordan
Burden of respiratory syncytial virus in hospitalized infants and young children in Amman, Jordan
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DOI：
10.3109/00365540903496544
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发表时间：
2010-05-01
影响因子：
--
通讯作者：
Halasa, Natasha B.
中科院分区：
文献类型：
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作者：
Khuri-Bulos, Najwa;Williams, John V.;Halasa, Natasha B.
急性呼吸道感染 (ARI) 在中东地区的住院治疗中发挥着重要作用，但具体的病毒原因尚不清楚。在呼吸道合胞病毒 (RSV) 高峰季节，我们对约旦安曼两家不同医院因急性呼吸道感染和/或发烧入院的 5 岁以下儿童进行了前瞻性病毒监测。我们收集了前瞻性临床和人口统计数据，并获取了鼻/咽拭子，用于通过实时聚合酶链反应 (RT-PCR) 检测 RSV。我们获得了 728/743 (98%) 名受试者的临床和实验室数据。儿童的中位年龄为 4.3 个月，58.4% 为男性，87% 接受母乳喂养，4% 接受日托，67% 接触吸烟者，7% 住进重症监护室，0.7% 死亡 (n = 5)。在 728 名受试者中，467 名受试者 (64%) 通过 RT-PCR 检测出 RSV 呈阳性。比较 RSV 阳性受试者与 RSV 阴性受试者，RSV 阳性受试者的中位年龄较低（3.6 个月 vs 6.4 个月，p < 0.001），且男性较少（55% vs 64%，p = 0.02）。与 RSV 阴性儿童相比，RSV 阳性儿童的氧气使用率较高（72% vs 42%，p < 0.001），住院时间较长（5 天 vs 4 天，p = 0.001），住院费用较高（538 美元 vs 431 美元，p < 0.001）。在约旦住院的年轻婴儿中，呼吸道合胞病毒造成的医疗和经济负担很高。 RSV 疫苗等有效的预防措施将产生显着的有益影响。
Acute respiratory infections (ARI) play a major role in hospitalizations in the Middle East, but the specific viral causes are unknown. We conducted prospective viral surveillance in children < 5 y of age admitted with ARI and/or fever at 2 dissimilar hospitals in Amman, Jordan during peak respiratory syncytial virus (RSV) season. We collected prospective clinical and demographic data and obtained nose/throat swabs for testing for RSV by real-time polymerase chain reaction (RT-PCR). We obtained clinical and laboratory data for 728/743 (98%) subjects enrolled. The children's median age was 4.3 months, 58.4% were males, 87% were breastfed, 4% attended day care, 67% were exposed to smokers, 7% were admitted to the intensive care unit, and 0.7% died (n = 5). Out of 728 subjects, 467 (64%) tested positive by RT-PCR for RSV. Comparing RSV-positive with RSV-negative subjects, the RSV-positive subjects had lower median age (3.6 vs 6.4 months, p < 0.001) and fewer males (55% vs 64%, p = 0.02). RSV-positive children had higher rates of oxygen use (72% vs 42%, p < 0.001), a longer hospital stay (5 vs 4 days, p = 0.001), and higher hospital charges (US$538 vs US$431, p < 0.001) than RSV-negative children. In young hospitalized Jordanian infants, the medical and financial burden of RSV was found to be high. Effective preventive measures, such as an RSV vaccine, would have a significant beneficial impact.