Ets transcription factors in intestinal morphogenesis, homeostasis and disease.
Ets transcription factors in intestinal morphogenesis, homeostasis and disease.
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DOI：
10.14670/hh-23.1417
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发表时间：
2008-11
影响因子：
2
通讯作者：
Gutierrez-Hartmann A
中科院分区：
文献类型：
--
作者：
Jedlicka P;Gutierrez-Hartmann A
Ets转录因子包括一个大家族的基因表达的序列特异性调节因子，在发育和疾病中具有重要和多样的作用。大多数Ets家族成员在发育和/或成熟的肠中表达，通常以隔室特异性和时间动态的方式表达。然而，除了高表达的Elf 3，参与胚胎上皮分化，很少有人知道Ets在肠道发育和稳态的功能。Ets因子在结肠癌中表现出改变的表达，它们调节与肿瘤进展相关的途径。Ets因子也可能通过调节与组织损伤和修复相关的途径而作为非肿瘤性肠道疾病的重要调节剂。尽管有大量关于Ets生物学的已发表工作，但关于这个庞大而多样的基因家族在肠道形态发生、体内平衡以及肿瘤和非肿瘤病理学中的确切功能，仍有许多有待了解。
Ets transcription factors comprise a large family of sequence-specific regulators of gene expression with important and diverse roles in development and disease. Most Ets family members are expressed in the developing and/or mature intestine, frequently in a compartment-specific and temporally dynamic manner. However, with the exception of the highly expressed Elf3, involved in embryonic epithelial differentiation, little is known about Ets functions in intestinal development and homeostasis. Ets factors show altered expression in colon cancer, where they regulate pathways relevant to tumor progression. Ets factors also likely act as important modifiers of non-neoplastic intestinal disease by regulating pathways relevant to tissue injury and repair. Despite a large body of published work on Ets biology, much remains to be learned about the precise functions of this large and diverse gene family in intestinal morphogenesis, homeostasis, and both neoplastic and non-neoplastic pathology.