Initial experience of correlating parameters of intravoxel incoherent motion and dynamic contrast-enhanced magnetic resonance imaging at 3.0 T in nasopharyngeal carcinoma
Initial experience of correlating parameters of intravoxel incoherent motion and dynamic contrast-enhanced magnetic resonance imaging at 3.0 T in nasopharyngeal carcinoma
复制标题
鼻咽癌体素内不相干运动与3.0T动态增强磁共振成像相关参数的初步经验
DOI：
10.1007/s00330-014-3343-2
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发表时间：
2014-12-01
影响因子：
5.9
通讯作者：
Liang, Chang-Hong
中科院分区：
文献类型：
--
作者：
Jia, Qian-Jun;Zhang, Shui-Xing;Liang, Chang-Hong
为了确定体素内非相干运动(IVIM)与动态增强磁共振成像(DCE)参数的相关性，38例新诊断的鼻咽癌患者进入前瞻性研究。使用3.0T磁共振成像系统采集13b值的弥散加权图像(DWI)。IVIM参数包括纯分子扩散(D)、灌注相关扩散(D*)、灌注分数(F)，DCE-MRI参数包括最大增加斜率(MSI)、增强幅度(Ea)和增强比(ER)。使用组内相关系数(ICC)和Bland-Altman分析评估观察者内和观察者间的一致性。观察者内和观察者间的重复性良好到较好(ICC=0.887~0.997；狭窄的95%符合范围)。F与Ea的相关性最高(r=0.633，P<0.001)，与MSI的相关性最强(r=0.598，P=0.001)。F与ER(r=-0.162；P=0.421)或D*与DCE参数(r=0.125-0.307；P>；0.119)之间无相关性。本研究表明3.0TMRI的IVIM灌注成像在鼻咽癌中是可行的，并且f与EA和MSI显著相关。
To determine the correlation between intravoxel incoherent motion (IVIM) and dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) parameters.Thirty-eight newly diagnosed NPC patients were prospectively enrolled. Diffusion-weighted images (DWI) at 13 b-values were acquired using a 3.0-T MRI system. IVIM parameters including the pure molecular diffusion (D), perfusion-related diffusion (D*), perfusion fraction (f), DCE-MRI parameters including maximum slope of increase (MSI), enhancement amplitude (EA) and enhancement ratio (ER) were calculated by two investigators independently. Intra- and interobserver agreement were evaluated using the intraclass correlation coefficient (ICC) and Bland-Altman analysis. Relationships between IVIM and DCE-MRI parameters were evaluated by calculation of Spearman's correlation coefficient.Intra- and interobserver reproducibility were excellent to relatively good (ICC = 0.887-0.997; narrow width of 95 % limits of agreement). The highest correlation was observed between f and EA (r = 0.633, P < 0.001), with a strong correlation between f and MSI (r = 0.598, P = 0.001). No correlation was observed between f and ER (r = -0.162; P = 0.421) or D* and DCE parameters (r = 0.125-0.307; P > 0.119).This study suggests IVIM perfusion imaging using 3.0-T MRI is feasible in NPC, and f correlates significantly with EA and MSI.aEuro cent Assessment of tumour perfusion is important in nasopharyngeal carcinoma.aEuro cent DCE-MRI provided perfusion information with the use of intravenous contrast media.aEuro cent Perfusion information could be provided by non-invasive IVIM MRI.aEuro cent IVIM parameter f correlated with DCE-MRI parameters.