Natural antisense transcripts are co-expressed with sense mRNAs in synaptoneurosomes of adult mouse forebrain
Natural antisense transcripts are co-expressed with sense mRNAs in synaptoneurosomes of adult mouse forebrain
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DOI：
10.1016/j.neures.2008.08.010
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发表时间：
2008-12-01
影响因子：
2.9
通讯作者：
Abe, Kuniya
中科院分区：
文献类型：
--
作者：
Smalheiser, Neil R.;Lugli, Giovanni;Abe, Kuniya
天然反义转录物和重叠正义转录物在多种组织中表达，包括成年小鼠脑。在这里，我们表明，一个子集的mRNA样的正义-反义转录本对共表达的成年小鼠前脑，一个亚细胞部分，是丰富的捏断树突棘的锥体神经元内synaptoneurosomes。这些对中的几个涉及与突触功能和阿尔茨海默病通路有关的mRNA。这项研究提供了证据表明，一类新的非编码RNA（天然反义转录本）在突触附近表达，并鼓励进一步研究它们在神经元功能中的作用。(C)2008年爱思唯尔爱尔兰有限公司和日本神经科学学会。All rights reserved.
Natural antisense transcripts and overlapping sense transcripts are expressed in a variety of tissues, including adult mouse brain. Here we show that a subset of mRNA-like sense-antisense transcript pairs are co-expressed within synaptoneurosomes of adult mouse forebrain, a subcellular fraction that is enriched in pinched-off dendritic spines of pyramidal neurons. Several of these pairs involve mRNAs that have been implicated in synaptic functions and in Alzheimer disease pathways. This study provides evidence that a new class of noncoding RNAs (natural antisense transcripts) are expressed near synapses, and encourages further studies of their roles in neuronal function. (C) 2008 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.