Cognitive deficit in 7-year-old children with prenatal exposure to methylmercury
Cognitive deficit in 7-year-old children with prenatal exposure to methylmercury
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DOI：
10.1016/s0892-0362(97)00097-4
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发表时间：
1997-11-01
影响因子：
2.9
通讯作者：
Jorgensen, PJ
中科院分区：
文献类型：
--
作者：
Grandjean, P;Weihe, P;Jorgensen, PJ
1986年至1987年期间，法罗群岛产生了1 022个连续单胎分娩的队列。脐带血和母亲毛发中的汞浓度表明，母亲食用领航鲸肉导致甲基汞暴露增加。在大约7岁时，917名儿童接受了详细的神经行为检查。神经心理学测试包括手指敲击;手眼协调;连续操作测试的反应时间;韦氏儿童智力量表-修订的数字跨度、相似性和块设计;本德视觉运动完形测试;波士顿视觉运动完形测试;和加州言语学习测试（儿童）。临床检查和神经生理学测试没有发现任何明确的汞相关异常。然而，汞相关的神经心理功能障碍在语言、注意力和记忆方面最为明显，在视觉空间和运动功能方面次之。这些协会仍然调整后的协变量和排除后，母亲头发汞浓度超过10微克/克（50 nmol/g）的儿童。因此，与产前甲基汞接触相关的脑功能影响似乎很普遍，在目前认为安全的接触水平下，可以检测到早期功能障碍。(C)1997年爱思唯尔科学公司
A cohort of 1022 consecutive singleton births was generated during 1986-1987 in the Faroe Islands. Increased methylmercury exposure from maternal consumption of pilot whale meat was indicated by mercury concentrations in cord blood and maternal hair. At approximately 7 years of age, 917 of the children underwent detailed neurobehavioral examination. Neuropsychological tests included Finger Tapping; Hand-Eye Coordination; reaction time on a Continuous Performance Test; Wechsler Intelligence Scale for Children-Revised Digit Spans, Similarities, and Block Designs; Bender Visual Motor Gestalt Test; Boston Naming Test; and California Verbal Learning Test (Children). Clinical examination and neurophysiological testing did not reveal any clear-cut mercury-related abnormalities. However, mercury-related neuropsychological dysfunctions were most pronounced in the domains of lan guage, attention, and memory, and to a lesser extent in visuospatial and motor functions. These associations remained after adjustment for covariates and after exclusion of children with maternal hair mercury concentrations above 10 mu g/g (50 nmol/g). The effects on brain function associated with prenatal methylmercury exposure therefore appear widespread, and early dysfunction is detectable at exposure levels currently considered safe. (C) 1997 Elsevier Science Inc.