The Microcystic, Elongated, and Fragmented (MELF) Pattern of Invasion A Single Institution Report of 464 Consecutive FIGO Grade 1 Endometrial Endometrioid Adenocarcinomas
The Microcystic, Elongated, and Fragmented (MELF) Pattern of Invasion A Single Institution Report of 464 Consecutive FIGO Grade 1 Endometrial Endometrioid Adenocarcinomas
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DOI：
10.1097/pas.0000000000000754
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发表时间：
2017-01-01
影响因子：
5.6
通讯作者：
Suarez, Adrian A.
中科院分区：
文献类型：
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作者：
Joehlin-Price, Amy S.;McHugh, Kelsey E.;Suarez, Adrian A.
在多机构病例对照研究中，MELF侵袭与非阴道复发和淋巴结（LN）转移有关，但尚未在大型单机构队列中得到很好的检验。对2007 - 2012年FIGO 1子宫内膜样子宫内膜癌和淋巴结切除术的子宫切除术标本进行鉴定。回顾了电子病历和组织学切片。在464例确诊病例中，163例（35.1%）为无创性，60例（12.9%）为MELF， 222例（47.8%）为浸润性侵袭，无MELF， 13例（2.8%）为纯推边界侵袭，5例（1.1%）为纯腺肌病样侵袭，1例（0.2%）为纯腺瘤样侵袭。16例发生淋巴结转移。总体而言，MELF患者的LNs阳性比例明显高于非MELF患者(18.3% vs. 1.2%， P
MELF invasion has been associated with nonvaginal recurrences and lymph node (LN) metastases in multi-institutional case control studies but has not been well examined in large single-institution cohorts. Hysterectomy specimens with FIGO 1 endometrioid endometrial carcinoma and lymphadenectomies from 2007 to 2012 were identified. Electronic medical records and histologic slides were reviewed. Of 464 identified cases, 163 (35.1%) were noninvasive, 60 (12.9%) had MELF, 222 (47.8%) had a component of the infiltrative invasion pattern without MELF, 13 (2.8%) had pure pushing borders of invasion, 5 (1.1%) had pure adenomyosis-like invasion, and 1 (0.2%) had pure adenoma malignum-like invasion. Sixteen cases had LN metastases. Significantly more MELF cases had positive LNs than non-MELF cases overall (18.3% vs. 1.2%, P