Hippocampal subfield volumes at 7T in early Alzheimer's disease and normal aging
Hippocampal subfield volumes at 7T in early Alzheimer's disease and normal aging
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DOI：
10.1016/j.neurobiolaging.2014.02.021
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发表时间：
2014-09-01
影响因子：
4.2
通讯作者：
Geerlings, Mirjam I.
中科院分区：
文献类型：
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作者：
Wisse, Laura E. M.;Biessels, Geert Jan;Geerlings, Mirjam I.
我们比较了轻度认知损害(MCI)、阿尔茨海默病(AD)患者和无认知损害的对照组的海马亚区和内嗅皮层(ERC)体积。此外，我们还研究了对照组年龄与海马区和ERC的关系。我们对16例遗忘型MCI患者、9例AD患者和29例对照组进行了0.7 mm(3)7特斯拉超高场磁共振成像。在T2加权像上追踪ERC、下丘、羊角(CA)1、CA2、CA3和齿状回(DG)和CA4。经年龄、性别和颅内体积调整后的协方差分析显示，与对照组和MCI患者相比，AD患者的ERC、下丘脑、CA1、CA3、DG和CA4体积显著减小。趋势分析显示，ERC与海马亚区和诊断组之间存在相似的关联。年龄越大，CA1和DG&CA4体积越小。总而言之，与对照组和MCI患者相比，AD患者几乎所有的海马区和ERC都显示出体积缩小。未来，更大规模的研究应该确定哪些亚区在疾病过程中最早受到影响，以及体积损失背后的机制。(C)2014 Elsevier Inc.保留所有权利。
We compared hippocampal subfield and entorhinal cortex (ERC) volumes between patients with mild cognitive impairment (MCI), Alzheimer's disease (AD), and controls without cognitive impairment. Additionally, we investigated the relation between age and hippocampal subfields and ERC in controls. We performed ultra-high field 0.7 mm(3) 7Tesla magnetic resonance imaging in 16 patients with amnestic MCI, 9 with AD, and 29 controls. ERC, subiculum, cornu ammonis (CA) 1, CA2, CA3, and dentate gyrus (DG) &CA4 were traced on T2-weighted images. Analyses of covariance, adjusted for age, sex, and intracranial volume showed that compared with controls and patients with MCI, patients with AD had significantly smaller ERC, subiculum, CA1, CA3, and DG&CA4 volumes. Trend analyses revealed similar associations between ERC and hippocampal subfields and diagnostic group. Older age was significantly associated with smaller CA1 and DG&CA4 volumes. In conclusion, almost all hippocampal subfields and ERC show volume reductions in patients with AD compared with controls and patients with MCI. Future, larger studies should determine which subfields are affected earliest in the disease process and what mechanisms underlie the volume loss. (C) 2014 Elsevier Inc. All rights reserved.