Gastrointestinal myoelectric correlates of vomiting in the dog.
Gastrointestinal myoelectric correlates of vomiting in the dog.
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胃肠道肌电与狗的呕吐相关。
DOI：
10.1152/ajpgi.1986.251.6.g830
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
Condon,RE
中科院分区：
文献类型：
--
作者：
Lang,IM;Marvig,J;Sarna,SK;Condon,RE
呕吐之前，连续发生两个胃肠道收缩事件：从中小肠逆行传播到胃窦（RGC）的巨大收缩和在胃肠道各级发生的一系列阶段性收缩。我们定量检查了与呕吐相关的胃肠道肌电事件，并将其与先前定义的收缩事件相关联。十二只不同性别的狗的胃和小肠上植入了电子或收缩记录装置。禁食过夜后，记录阿朴吗啡给药前后的肠道活动（2.5-15 微克/千克，静脉注射）。我们发现 RGC 与两个连续的电事件相关：电控制活动 (ECA) 循环的中断和 RGC 上行时发生的潜在变化。然而，与呕吐相关的最初肌电事件是胃窦和小肠下半部的 ECA 频率减慢。 RGC 后阶段性收缩与 ECA 依赖性反应活动相关，并发生在 ECA 频率减慢期间。阿托品（100 微克/千克，静脉注射）可阻断 RGC 及其相关电事件，但不会减缓 ECA 频率。膈上迷走神经切断术消除了所有胃肠道收缩和肌电事件，但窦 ECA 频率减慢。呕吐的肌电相关性的自发发生与阿扑吗啡激活的肌电相关性没有什么不同。这些结果表明 ECA 破坏可能对 RGC 的逆行传播很重要。然而，ECA 频率减慢的功能仍然未知。
Prior to vomiting, two gastrointestinal contractile events occur in succession: a giant contraction that propagates retrograde from mid-small intestine to the antrum (RGC) and a series of phasic contractions that occur at all levels of the gastrointestinal tract. We quantitatively examined the gastrointestinal myoelectric events associated with vomiting and correlated them with the previously defined contractile events. Twelve dogs of either sex were implanted with electrical or contractile recording devices implanted on the stomach and small intestine. After an overnight fast, gut activity was recorded before and after apomorphine administration (2.5–15 micrograms/kg, iv). We found that the RGC was correlated with two successive electrical events: disruption of electrical control activity (ECA) cycling and a potential change occurring at the upstroke of the RGC. However, the initial myoelectric event associated with vomiting was ECA frequency slowing of the antrum and lower half of the small intestine. The post-RGC phasic contractions were associated with ECA-dependent response activity and occurred during the period of ECA frequency slowing. Atropine (100 micrograms/kg iv) blocked the RGC and its associated electrical events but not the slowing of ECA frequency. Supradiaphragmatic vagotomy eliminated all gastrointestinal contractile and myoelectric events but antral ECA frequency slowing. Spontaneous occurrences of the myoelectric correlates of vomiting were not different from those activated by apomorphine. These results suggest that ECA disruption may be important for retrograde propagation of the RGC. The function of ECA frequency slowing, however, remains unknown.