Formation of platinum (II) as a six member ring for sustained polymeric delivery.
Formation of platinum (II) as a six member ring for sustained polymeric delivery.
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形成六元环铂 (II)，以实现持续的聚合物输送。
DOI：
10.1016/j.ejmech.2017.05.020
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发表时间：
2017
影响因子：
6.7
通讯作者：
Forrest,MLaird
中科院分区：
文献类型：
--
作者：
Senadheera,SanjeewaN;Zhang,Ti;Groer,ChadE;Forrest,MLaird
A new pH-activated polymer chelate of cisplatin was synthesized using a scalable and green aqueous technique. Synthesis of the chelate was based on formation of a 6-member ring of platinum(II) with acetyl-homo-Lysine (Ac-homo-Lys), which was accomplished under completely aqueous conditions using a traceless photocleavable protection chemistry. Synthesis preceded by, first, amidation of a photocaged homo-Ac-Lys with hyaluronic acid (HA) in water using ap-hydroxyphenacyl (pHP) group as the photoremovable protecting group, followed by reaction of cisplatin (diaqua form) in water to form the reversible chelate. Platinum drug release was pH rate controlled, with more rapid release (t1/220 h) at acidic pH similar to the tumor microenvironment yet slower release (t1/235 h) at normal physiological pH.
影响因子：
3.8
作者：
Cai, Shuang;Xie, Yumei;Davies, Neal M.;Cohen, Mark S.;Forrest, M. Laird
通讯作者：
Forrest, M. Laird
二烷基双(三乙基膦)铂(II)络合物的环金属化：形成Pt,Pt-双(三乙基膦)铂环烷烃
DOI：
--
发表时间：
1982
期刊：
影响因子：
--
作者：
R. Dicosimo;S. S. Moore;A. Sowinski;G. Whitesides
通讯作者：
G. Whitesides