The met receptor tyrosine kinase and basal breast cancer
The met receptor tyrosine kinase and basal breast cancer
复制标题
DOI：
10.4161/cc.9.6.11033
复制
发表时间：
2010-03-15
期刊：
影响因子：
4.3
通讯作者：
Park, Morag
中科院分区：
文献类型：
--
作者：
Ponzo, Marisa G.;Park, Morag
乳腺癌是一种复杂的疾病，包括不同生物学和治疗反应的癌症。临床管理依赖于传统的临床病理学参数，包括淋巴结状态、组织学分级以及雌激素受体或人表皮生长因子受体2的表达。分子病理学以及蛋白质和基因表达谱将乳腺肿瘤分为与不同临床结果相关的分子亚型。其中之一，被定义为基底乳腺癌，与预后不良有关。基底层乳腺癌诱导的分子机制知之甚少，缺乏针对该亚型的靶向治疗。最近使用鼠模型的证据确定了Met受体酪氨酸激酶在诱导具有人基底乳腺癌特征的鼠乳腺肿瘤中的作用。此外，升高的Met蛋白和RNA与人类基底肿瘤和不良结局相关。这些研究确定了Met受体酪氨酸激酶、上皮间质转化和基底乳腺癌之间的联系。在这篇综述中，我们提供了一个概述的鼠Met模型的光谱的小鼠模型的乳腺癌和Met受体在基底乳腺癌肿瘤发生的作用。
Breast cancer is a complex disease that comprises cancers of distinct biologies and responses to treatment. Clinical management relies on traditional clinicopathological parameters, involving lymph node status, histological grade, as well as expression of the estrogen receptor or human epidermal growth factor receptor 2. Molecular pathology as well as protein and gene expression profiling have divided breast tumors into molecular subtypes associated with different clinical outcomes. One of these, defined as basal breast cancer, is associated with poor prognosis. Molecular mechanisms involved in the induction of basal breast cancer are poorly understood and targeted therapies for this subtype are lacking. Recent evidence using murine models identified a role for the Met receptor tyrosine kinase in the induction of murine mammary tumors with characteristics of human basal breast cancers. Moreover, elevated Met protein and RNA is associated with human basal tumors and poor outcome. These studies identify a link between the Met receptor tyrosine kinase, epithelial mesenchymal transition, and basal breast cancer. In this review, we provide an overview of murine Met models in relation to the spectrum of mouse models of breast cancer and a role for the Met receptor in basal breast cancer tumorigenesis.