Effects of naloxone on plasma corticosterone in the opiate-naive rat.
Effects of naloxone on plasma corticosterone in the opiate-naive rat.
复制标题
纳洛酮对未服用阿片类药物的大鼠血浆皮质酮的影响。
DOI：
10.1016/0024-3205(80)90114-9
复制
发表时间：
1980
期刊：
影响因子：
6.1
通讯作者：
R. Eisenberg
中科院分区：
文献类型：
--
作者：
R. Eisenberg
盐酸纳洛酮（NX）长期以来一直被认为是一种纯麻醉拮抗剂，只有在用麻醉剂预处理后才有效。典型地，低剂量的NX已被用于拮抗镇痛剂量的麻醉剂的作用，并在长期治疗的动物中促使戒断。在本研究中，在未使用过阿片类药物的动物中检查了高剂量NX（2.0 - 20.0 mg/kg）对血浆皮质酮变化的影响。使用带有慢性静脉导管和单向视觉箱的雄性大鼠，进行注射，并在清醒、不受约束的动物中获得系列血样。急性给药的阿片类药物的幼稚动物产生了剂量相关的增加血浆皮质酮的幅度和持续时间。NX（10.0 mg/kg i.v.）在15分钟和30分钟时激素水平显着升高。与NX（20.0 mg/kg i.v.）回应时间延长至六十分钟。为了检查是否可以产生对这种效应的短期耐受性，动物被给予NX（10.0 mg/kg）或生理盐水静脉注射的单一预处理。两小时后，NX在两组中产生了相似的激素水平升高。并观察了慢性注射NX的效果。用NX（10.0 mg/kg）或生理盐水s.c.预处理的动物在随后的NX给药后，每天一次持续7天没有显示出显著差异。在这两种情况下，导致血浆皮质酮显著升高。结果表明，NX可能对阿片受体产生直接影响，导致血浆激素水平升高，或NX可能破坏内源性阿片受体相互作用，产生应激反应。
Naloxone HCl (NX) has long been considered to be a pure narcotic antagonist, having an effect only subsequent to pretreatment with a narcotic. Characteristically, low doses of NX have been used to antagonize the effects of analgesic doses of narcotics and to precipitate withdrawal in chronically treated animals. In this study, the effects of high doses of NX (2.0–20.0 mg/kg) on changes in plasma corticosterone were examined in the opiate-naive animal. Using male rats with chronic intravenous catheters and one-way vision boxes, injections were made and serial blood samples were obtained in the conscious, unrestrained animal. The acute administration of NX to the opiate-naive animal produced a dose-related increase in plasma corticosterone with respect to both amplitude and duration. NX (10.0 mg/kg i.v.) produced a significant elevation in hormone level at 15 and 30 minutes. With NX (20.0 mg/kg i.v.) the duration of the response was extended to 60 minutes. To examine whether short-term tolerance to this effect could be produced, animals were given a single pretreatment with either NX (10.0 mg/kg) or saline i.v. Two hours later NX produced a similar elevation in hormone level in both groups. The effect of chronic injection of NX was also studied. Animals pretreated with either NX (10.0 mg/kg) or saline s.c. once daily for 7 days did not show a significant difference following the subsequent administration of NX. In both cases, a significant elevation of plasma corticosterone resulted. The results suggest that NX may have a direct effect on opiate receptors resulting in an elevation of plasma hormone levels or NX may be disrupting an endogenous opiate-receptor interaction producing a stress response.