OLIVOCEREBELLAR SYSTEM .1. DELAYED AND SLOW INHIBITORY EFFECTS - OVERLOOKED SALIENT FEATURE OF CEREBELLAR CLIMBING FIBERS
OLIVOCEREBELLAR SYSTEM .1. DELAYED AND SLOW INHIBITORY EFFECTS - OVERLOOKED SALIENT FEATURE OF CEREBELLAR CLIMBING FIBERS
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DOI：
10.1016/0006-8993(80)90491-6
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发表时间：
1980-01-01
期刊：
影响因子：
2.9
通讯作者：
DESCLIN, JC
中科院分区：
文献类型：
--
作者：
COLIN, F;MANIL, J;DESCLIN, JC
对大鼠下橄榄核 (ION) 或中断攀爬纤维 (CF) 的中线部分的化学破坏迅速导致浦肯野细胞 (P 细胞) 单尖峰 (SS) 放电速率和模式的显着改变。 CF 传入阻滞后，P 细胞最初将其 SS 频率加倍，并在接下来的 10 分钟内进一步增加。除了放电率增加之外，尖峰序列变得更加规则，这在一定程度上似乎与神经元电路的大规模振荡有关，正如背景噪声的强烈振荡所揭示的那样。离子破坏后，CF 活动可以通过近视顶 (JF) 刺激来提供，这再次降低了 SS 频率，同时放电变得不那么规律。这些效应是由于 CF 的全有或全无活动造成的，而不是由于苔藓纤维 (MF) 或 P 细胞轴突的同时刺激。它们也不能归因于 CF 抵押品。讨论了 CF 系统对 P 细胞的这种新的强大抑制作用与有据可查的暂停机制之间的差异。在复杂尖峰 (CS) 和 SS 发射率之间建立了定量关系。稳定的 2/s CS 频率有效地使 P 细胞安静。当 CF 刺激停止时，描述了关闭效应。它包括在 9 秒内发展的 SS 频率的初始上升，以及在约 10 分钟内展开的延迟的进一步增加。当 CF 刺激开始时，观察到了一种效应，这种效应以指数型动力学的方式演变，时间常数变化很大，似乎取决于过去的历史。
Chemical destruction of the rat inferior olive (ION), or midline section interrupting the climbing fibers (CF) rapidly resulted in marked modifications of Purkinje cell (P cell) simple spike (SS) firing rate and pattern. After CF deafferentation, P cells initially doubled their SS frequency which further increased for the next 10 min. Besides the increase in the firing rate, the spike train became much more regular, which in part seemed to be linked to mass oscillations of the neuronal circuitry, as revealed by strong oscillations of background noise. After ION destruction CF activity could be supplied for by juxtafastigial (JF) stimulation which reduced SS frequency again while the firing became much less regular. These effects were due to the all-or-nothing activity of the CF and not to the simultaneous stimulation of mossy fibers (MF) or P cell axons. Neither were they ascribable to CF collaterals. The differences between this new powerful inhibitory action of the CF system on the P cell and the well documented pause mechanism is discussed. A quantitative relationship was established between complex spikes (CS) and SS firing rates. A steady 2/s CS frequency effectively silenced the P cell. When CF stimulation was discontinued, an off effect was described. It consisted of an initial rise in SS frequency developing in 9 s, and a delayed further increase unfolding in about 10 min. When CF stimulation began, an on effect was observed, which evolved with an exponential-like kinetic of very variable time-constant, seemingly depending on past history.