Single-Molecule Electrical Biosensors Based on Single-Walled Carbon Nanotubes
Single-Molecule Electrical Biosensors Based on Single-Walled Carbon Nanotubes
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DOI：
10.1002/adma.201301219
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发表时间：
2013-07-05
影响因子：
29.4
通讯作者：
Guo, Xuefeng
中科院分区：
文献类型：
--
作者：
Guo, Xuefeng
生物分子之间的相互作用是生物学的基础。在分子水平上探索生物系统的复杂行为提供了新的机会，可以揭示通常隐藏在传统集合实验中的分子信息，并解决物理，化学和生物科学中无法回答的问题。纳米级材料由于其生物相容性、尺寸可比性和显著的电学性质而与生物分子相互作用特别匹配，从而为具有生物敏感性的生物传感奠定了基础。本文综述了近年来基于纳米材料的单分子电生物传感器的研究进展，重点介绍了单壁碳纳米管（SWNTs）的结构、相互作用动力学和分子功能。本文还讨论了下一代单分子生物传感器在实际应用中取得成功的前景和关键问题，如器件的可重复性、系统集成和理论模拟。
Interactions between biological molecules are fundamental to biology. Probing the complex behaviors of biological systems at the molecular level provides new opportunities to uncover the wealth of molecular information that is usually hidden in conventional ensemble experiments and address the unanswerable questions in the physical, chemical and biological sciences. Nanometer-scale materials are particularly well matched with biomolecular interactions due to their biocompatibility, size comparability, and remarkable electrical properties, thus setting the basis for biological sensing with ultrahigh sensitivity. This brief review aims to highlight the recent progress of the burgeoning field of single-molecule electrical biosensors based on nanomaterials, with a particular focus on single-walled carbon nanotubes (SWNTs), for better understanding of the molecular structure, interacting dynamics, and molecular functions. The perspectives and key issues that will be critical to the success of next-generation single-molecule biosensors toward practical applications are also discussed, such as the device reproducibility, system integration, and theoretical simulation.