Bioelectronic silicon nanowire devices using functional membrane proteins
Bioelectronic silicon nanowire devices using functional membrane proteins
复制标题
DOI：
10.1073/pnas.0904850106
复制
发表时间：
2009-08-18
影响因子：
11.1
通讯作者：
Noy, Aleksandr
中科院分区：
文献类型：
--
作者：
Misra, Nipun;Martinez, Julio A.;Noy, Aleksandr
现代通信手段依靠电场和电流来传输信息。相比之下，生物系统遵循不同的范式，使用离子梯度和电流，小分子的流动和膜电位。生物体使用复杂的膜受体、通道和泵来控制信号转导，其程度是人造装置无法比拟的。使用这种生物组件的电子电路可以实现大幅增加的功能;然而，这种方法需要生物和人造结构的几乎无缝集成。我们提出了一个通用的混合平台，这样的集成，使用屏蔽纳米线（NW），涂有连续的脂质双层。我们表明，当屏蔽硅NW晶体管将跨膜肽孔短杆菌肽A和丙甲菌素在脂质双层，他们可以实现离子到电子信号转导通过使用电压门控或化学门控离子运输通过膜孔。
Modern means of communication rely on electric fields and currents to carry the flow of information. In contrast, biological systems follow a different paradigm that uses ion gradients and currents, flows of small molecules, and membrane electric potentials. Living organisms use a sophisticated arsenal of membrane receptors, channels, and pumps to control signal transduction to a degree that is unmatched by manmade devices. Electronic circuits that use such biological components could achieve drastically increased functionality; however, this approach requires nearly seamless integration of biological and manmade structures. We present a versatile hybrid platform for such integration that uses shielded nanowires (NWs) that are coated with a continuous lipid bilayer. We show that when shielded silicon NW transistors incorporate transmembrane peptide pores gramicidin A and alamethicin in the lipid bilayer they can achieve ionic to electronic signal transduction by using voltage-gated or chemically gated ion transport through the membrane pores.