Resetting the rat circadian clock by ultra-short light flashes
Resetting the rat circadian clock by ultra-short light flashes
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DOI：
10.1016/s0304-3940(99)00021-x
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发表时间：
1999-02-19
影响因子：
2.5
通讯作者：
Amir, S
中科院分区：
文献类型：
--
作者：
Arvanitogiannis, A;Amir, S
我们研究了超短、强烈的闪光对大鼠下丘脑视交叉上核（SCN）生物钟的影响。我们发现，在持续黑暗的大鼠中，只要5次强烈的闪光，每次持续10 μ s（每秒1次），就能产生自由活动节律的相移和SCN中Fos表达。预暴露于这样的闪光后，响应于2小时后提供的连续光脉冲的相移被增强，但在SCN中的Fos表达降低，如以下预暴露于连续光。这些结果表明，闪光诱导的行为和细胞的影响，指示时钟重置类似的光刺激的持续时间较长。非常短暂但强烈的光刺激可能比以前所知的对时钟重置更重要。(C)1999爱思唯尔科学爱尔兰有限公司版权所有。
We examined the effects that ultra-brief, intense, light flashes have on the rat circadian clock, the suprachiasmatic nucleus of the hypothalamus (SCN), We found that as few as five intense flashes, each 10-mu s in duration (1 per s), can produce both phase shifts in free-running activity rhythms and Fos expression in the SCN in rats kept in constant darkness. After pre-exposure to such flashes, phase shifts in response to a continuous light pulse delivered 2 h later were potentiated, but Fos expression in the SCN was decreased as following pre-exposure to continuous light. These results show that flashes induce behavioral and cellular effects indicative of clock resetting similar to those induced by light stimuli of longer duration. Extremely brief but intense, light stimuli may be much more important to clock resetting than had been previously known. (C) 1999 Elsevier Science ireland Ltd. All rights reserved.