Modulation of Resting State Functional Connectivity of the Motor Network by Transcranial Pulsed Current Stimulation
Modulation of Resting State Functional Connectivity of the Motor Network by Transcranial Pulsed Current Stimulation
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通过颅脉冲电流刺激调节运动网络的静息状态功能连接
DOI：
10.1089/brain.2013.0196
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发表时间：
2014
影响因子：
3.4
通讯作者：
R. Gullapalli
中科院分区：
文献类型：
--
作者：
C. Sours;G. Alon;S. Roys;R. Gullapalli
研究了经颅脉冲电流刺激（tPCS）对运动网络内静息态功能连接（rs-FC）的影响。 11 名健康参与者接受了 1 次磁共振成像 (MRI) 治疗，其中包括 3 次静息态功能 MRI (rs-fMRI) 扫描，1 次在刺激前 (PRE-STIM) 扫描以收集基线测量值，1 次在刺激期间 (STIM)，1 次在刺激 13 分钟后 (POST-STIM)。将 STIM 和 STIM 后条件下的 Rs-FC 测量值与 PRE-STIM 基线进行比较。 rs-FC 分析的感兴趣区域是从手指敲击运动范例期间获得的显着激活的簇中提取的，包括右侧初级运动皮层 (R M1)、左侧初级运动皮层 (L M1)、辅助运动区 (SMA) 和小脑 (Cer)。主要发现是刺激期间左侧 M1 和周围运动皮层之间的 rs-FC 减少，左侧 M1 和左侧丘脑之间的 rs-FC 增加，但刺激后 Cer 和右侧岛叶之间的 rs-FC 增加。连接的双变量测量表明整个网络平均的连接强度降低（p=0.044），并且刺激期间网络平均的连接多样性降低（p=0.024）。在 POST-STIM 条件下，网络平均多样性减少的趋势在统计上较弱 (p=0.071)。总之，虽然许多研究结果与之前使用同步经颅直流电刺激 (tDCS) 和 fMRI 采集的报告相当，但我们还证明了 tPCS 引起的连接模式的额外变化。
The effects of transcranial pulsed current stimulation (tPCS) on resting state functional connectivity (rs-FC) within the motor network were investigated. Eleven healthy participants received one magnetic resonance imaging (MRI) session with three resting state functional MRI (rs-fMRI) scans, one before stimulation (PRE-STIM) to collect baseline measures, one during stimulation (STIM), and one after 13 min of stimulation (POST-STIM). Rs-FC measures during the STIM and POST-STIM conditions were compared to the PRE-STIM baseline. Regions of interest for the rs-FC analysis were extracted from the significantly activated clusters obtained during a finger tapping motor paradigm and included the right primary motor cortex (R M1), left primary motor cortex (L M1), supplemental motor area (SMA), and cerebellum (Cer). The main findings were reduced rs-FC between the left M1 and surrounding motor cortex, and increased rs-FC between the left M1 and left thalamus during stimulation, but increased rs-FC between the Cer and right insula after stimulations. Bivariate measures of connectivity demonstrate reduced strength of connectivity for the whole network average (p=0.044) and reduced diversity of connectivity for the network average during stimulation (p=0.024). During the POST-STIM condition, the trend of reduced diversity for the network average was statistically weaker (p=0.071). In conclusion, while many of the findings are comparable to previous reports using simultaneous transcranial direct current stimulation (tDCS) and fMRI acquisition, we also demonstrate additional changes in connectivity patterns that are induced by tPCS.