The microsatellite instable subset of colorectal cancer is a particularly good candidate for checkpoint blockade immunotherapy.
The microsatellite instable subset of colorectal cancer is a particularly good candidate for checkpoint blockade immunotherapy.
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DOI：
10.1158/2159-8290.cd-14-1397
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发表时间：
2015-01
期刊：
影响因子：
28.2
通讯作者：
Freeman GJ
中科院分区：
文献类型：
--
作者：
Xiao Y;Freeman GJ
结直肠癌（CRC）的微卫星不稳定（MSI）亚群表现出活跃的Th 1/CTL免疫微环境，这可能是由于识别大量的肿瘤新抗原。然而，MSI CRC中检查点分子PD-1、PD-L1、CTLA-4、LAG-3和IDO的高表达将MSI与微卫星稳定（MSS）CRC区分开来，并产生免疫抑制微环境，其可以帮助MSI肿瘤逃避浸润免疫细胞的免疫破坏。虽然CRC对PD-1通路免疫治疗的反应率不高，但这些结果表明CRC的MSI子集是检查点免疫治疗的特别好的候选者。
The microsatellite instable (MSI) subset of colorectal cancer (CRC) exhibits an active Th1/CTL immune microenvironment probably due to recognition of a high number of tumor neoantigens. However, the high expression of checkpoint molecules PD-1, PD-L1, CTLA-4, LAG-3, and IDO in MSI CRC distinguishes MSI from microsatellite stable (MSS) CRC and creates an immunosuppressive microenvironment that may help MSI tumors evade immune destruction by the infiltrating immune cells. Though CRC does not have a good response rate to PD-1 pathway immunotherapy, these results suggest that the MSI subset of CRC is a particularly good candidate for checkpoint immunotherapy.