Twin screw granulation: An evaluation of using micronized lactose as a solid binder
Twin screw granulation: An evaluation of using micronized lactose as a solid binder
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DOI：
10.1016/j.cherd.2018.03.021
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发表时间：
2018-05-01
影响因子：
3.9
通讯作者：
Salman, Agba D.
中科院分区：
文献类型：
--
作者：
Ai, Qing;Hounslow, Michael I.;Salman, Agba D.
在双螺杆湿法制粒工艺中，粘合赋形剂可以两种方式加入：制粒前与粉末材料预混合或溶解在水中作为溶液。本文考察了微粉化乳糖作为固体粘合剂赋形剂在双螺杆制粒工艺中的可行性。将不同比例的微粉化乳糖分别与乳糖和微晶纤维素（MCC）粉末混合，然后制粒。作为比较，在固相和液相中制备羟丙基纤维素（HPC）（即分别与粉末预混合并溶解为溶液）。通过研究微粉化乳糖和羟丙基纤维素对颗粒大小、形状和表面结构等性质的影响，进行制粒以考察结合潜力。由于其小尺寸，微粉化乳糖被证明是固体粘合赋形剂的理想替代品，可提供强粘合并生产具有改善粒度分布的颗粒。此外，还研究了微粉化乳糖在致密粉末床上的结合能力，研究了接触角、核硬度和表面结构。(C)2018化学工程师学会。Elsevier B.V.出版，保留所有权利。
In twin screw wet granulation process, the binding excipients could be added in two ways: premixed with powder materials before granulation or dissolved in water as a solution. In this paper, the feasibility of using micronized lactose as a solid binder excipient in twin screw granulation process was examined. Different proportions of micronized lactose were mixed with lactose and microcrystalline cellulose (MCC) powder before granulation, respectively. As a comparison, hydroxypropyl cellulose (HPC) was prepared in solid and liquid phase (i.e. premixed with powder and dissolved as solution respectively). Granulation was carried out to investigate the binding potential by studying the effect of micronized lactose and HPC on the granules properties such as size, shape and surface structure. Due to its small size, micronized lactose was proven to be an ideal alternative as a solid binding excipient to provide strong bonds and produce granules with improved granule size distributions. Furthermore, the binding capacity of micronized lactose was also examined on the compact powder bed where the contact angle, nucleus hardness and surface structure were studied. (C) 2018 Institution of Chemical Engineers. Published by Elsevier B.V. All rights reserved.