Genetic aberrations detected by comparative genomic hybridization in hepatocellular carcinomas: Their relationship to clinicopathological features
Genetic aberrations detected by comparative genomic hybridization in hepatocellular carcinomas: Their relationship to clinicopathological features
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DOI：
10.1002/hep.510290636
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发表时间：
1999-06-01
期刊：
影响因子：
13.5
通讯作者：
Sasaki, K
中科院分区：
文献类型：
--
作者：
Kusano, N;Shiraishi, K;Sasaki, K
为了阐明人类肝细胞癌（HCC）的细胞遗传学改变，我们使用比较基因组杂交（CGH）方法分析了41例肝细胞癌（HCC），包括15例高分化HCC，14例中分化HCC，12例低分化HCC。其中，27例患者慢性感染丙型肝炎病毒（HCV），其余患者为阳性的B肝炎病毒（HBV）。DNA拷贝数增加的最常见位点分别为1 q（78%的病例）和8 q（66%），1 q24 -25和8 q24的重叠区域最少。在17 p（51%）、16 q（46%）、13 q13 -14（37%）、4 q13 -22（32%）、8 p（29%）和10 q（17%）处观察到拷贝数频繁减少。在6例（15%）中，在11 q13区域发现扩增。8 q24的增加与高分化HCC显著相关（P
To elucidate cytogenetic alterations underlying human hepatocellular carcinomas (HCCs), we used a comparative genomic hybridization (CGH) method to analyze 41 cases of hepatocellular carcinoma (HCC) including 15 well differentiated HCCs, 14 moderately differentiated HCCs, and 12 poorly differentiated HCCs. Of these, 27 patients were chronically infected with hepatitis C virus (HCV), and the remaining patients were positive for hepatitis B virus (HBV). The most common sites of increase in DNA copy number were 1q (78% of the cases) and 8q (66%) with minimal overlapping regions at 1q24-25 and 8q24, respectively. Frequent decreases in copy number were observed at 17p (51%), 16q (46%), 13q13-14 (37%), 4q13-22 (32%), 8p (29%), and 10q (17%). In 6 cases (15%), an amplification was found in the region of 11q13. A gain of 8q24 was significantly associated with well-differentiated HCCs (P