THE METABOLISM OF DRUGS BY THE GUT FLORA
THE METABOLISM OF DRUGS BY THE GUT FLORA
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DOI：
10.1007/bf03188922
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发表时间：
1994-07-01
影响因子：
1.9
通讯作者：
MIKOV, M
中科院分区：
文献类型：
--
作者：
MIKOV, M
消化道植物群和内容物是一个具有巨大代谢能力的系统，在质和量上与机体细胞和器官不同。该系统随着生命和营养的变化而沿着变化，但尽管进行了广泛的调查，尚未得到令人满意的定义。在许多情况下，个体间和个体内药物代谢的差异可能与肠道植物群代谢的变化有关。药物和其他外源性代谢物在胆汁中排泄的肠道植物群代谢是负责肝肠循环的关键阶段。在过去的十年中，越来越多的证据表明肠道植物群半胱氨酸结合物β-裂解酶在半胱氨酸结合物代谢中的关键作用。对乙酰氨基酚半胱氨酸结合物代谢的一条新途径与肠道植物群活性直接相关，正如我们的研究所证明的那样，如今，肠道植物群代谢必须被视为药物代谢和毒性研究的组成部分。
Gut flora and gut contents can be considered as a system with huge metabolic capacity, qualitatively and quantitatively different from the body cells and organs. That system changes along with life and nutrition, but despite broad investigation has not yet been defined satisfactorily. In many cases inter individual and intra individual differences in drug metabolism could be linked to variations in the gut flora metabolism Gut flora metabolism of drugs and other xenobiotic metabolites excreted in bile is the key phase responsible for enterohepatic circulation.In the last decade there has been more and more evidence for the crucial role of the gut flora cysteine conjugate beta-lyase in the metabolism of cysteine conjugates. A new pathway for paracetamol cysteine conjugate metabolism has been directly linked with gut flora activity, as demonstrated in our studies.Nowadays, it is quite clear that gut flora metabolism must be considered an integral part of drug metabolism and toxicity studies.